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DOI: 10.1055/s-2001-11499
© Georg Thieme Verlag Stuttgart · New York
In Vitro Anti-Helicobacter pylori Activity of Irisolidone Isolated from the Flowers and Rhizomes of Pueraria thunbergiana
Publication History
March 23, 2000
June 4, 2000
Publication Date:
31 December 2001 (online)
![](https://www.thieme-connect.de/media/plantamedica/200102/lookinside/thumbnails/10.1055-s-2001-11499-1.jpg)
Abstract
The inhibitory effect of isoflavones isolated from the flowers and rhizomes of Pueraria thunbergiana (Leguminosae) on the growth of Helicobacter pylori (HP) was investigated. Isoflavone glycosides did not inhibit the growth of HP. However, their aglycones, irisolidone, tectorigenin and genistein, inhibited HP growth. Among them, irisolidone had the most potent inhibitory activity against HP and its MIC was 12.5 - 25 μg/ml. Genistein only weakly inhibited the urease of HP and H+/K+-ATPase of rat stomach: its IC50 were 0.43 and 0.89 mg/ml, respectively
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Prof. Dr. D.-H. Kim
College of Pharmacy,
Kyung-Hee University
1, Hoegi
Dongdaemum-ku
Seoul 130-701
Korea
Email: dhkim@nms.kyunghee.ac.kr
Fax: +82-2-957-5030