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Planta Med 2001; 67(2): 179-181
DOI: 10.1055/s-2001-11513
DOI: 10.1055/s-2001-11513
Letter
© Georg Thieme Verlag Stuttgart · New York
Modulatory Effect of Aliphatic Acid Amides from Zanthoxylum piperitum on Isolated Gastrointestinal Tract
Further Information
Publication History
March 23, 2000
July 16, 2000
Publication Date:
31 December 2001 (online)
![](https://www.thieme-connect.de/media/plantamedica/200102/lookinside/thumbnails/10.1055-s-2001-11513-1.jpg)
Abstract
β-Sanshool and γ-sanshool, unsaturated aliphatic acid amides isolated from the pericarpium of Zanthoxylum piperitum De Candolle (Rutaceae), relax the circular muscle of the gastric body, as well as contract the longitudinal muscle of the ileum and distal colon in an experimental system using the gastrointestinal tract isolated from a guinea pig.
References
- 1 Horie Y, Kato K, Hamano K. An overview of our surgery-oriented Kampo. Journal of Tokyo Women's Medical College. 1995; 65 43-51
- 2 Kurosawa S, Nishikawa S, Kaneko M, Nakamura T. The herbal medicine Dai-Kenchu-to contract guinea pig colon muscle while relax the gastric muscle. Gastroenterology. 1997; 112 A 768
- 3 Kurosawa S, Nishikawa S, Kaneko M, Ogiwara S, Ro S, Nakamura T, Saito K, Hayakawa T, Kase Y, Ishige A. The herbal medicine Dai-Kenchu-to contract guinea pig distal colon muscle through acetylcholine release. Gastroenterology. 1998; 114 A 782
- 4 Kurosawa S, Nishikawa S, Kaneko M, Ogiwara S, Ro S, Nakamura T, Saito K, Hashimoto K, Kase Y, Ishige A. Hydroxy-β-sanshool extracted from the herbal medicine Dai-Kenchu-to contracts the ileal and colonic muscle as well as relaxes the gastric muscle in the guinea pig. Gastroenterology. 1999; 116 A 1021
- 5 Yasuda I, Takeya K, Itokawa H. Two new pungent principles isolated from the pericarps of Zanthoxylum ailanthoides . Chemical Pharmaceutical Bulletin. 1981; 29 1791-3
- 6 Yasuda I, Takeya K, Itokawa H. Distribution of unsaturated aliphatic acid amides in Japanese Zanthoxylum species. Pyhtochemistry. 1982; 21 1295-8
- 7 Yasuda I, Takeya K, Itokawa H. Evaluation of Chinese Zanthoxyli Fructus commercially available in Japan by pungent principles and essential oil constituents. Shoyakugaku Zasshi. 1982; 36 301-6
- 8 Saitoh K, Kase Y, Ishige A, Komatsu Y, Sasaki H, Shibahara N. Effects of Keishi-ka-shakuyaku-to on diarrhea and small intestinal movement. Biological Pharmaceutical Bulletin. 1999; 22 87-9
Dr. Kazunori Hashimoto
Kampo & Pharmacognosy Laboratory
3586 Yoshiwara
Ami-machi
Inashiki-gun
Ibaraki 300-11
Japan
Email: hashimoto_kazunori@mail.tsumura.co.jp
Fax: +81-298-89-3832