Planta Med 2001; 67(2): 108-113
DOI: 10.1055/s-2001-11514
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Influence of Natural and Synthetic Compounds on Cell Surface Expression of Cell Adhesion Molecules, ICAM-1 and VCAM-1

Shigeo Tanaka1,*, Yoichi Sakata1 , Katsushi Morimoto2 , Yukihiro Tambe2 , Yoshihiko Watanabe2 , Gisho Honda2 , Mamoru Tabata2 , Tikashi Oshima3 , Toru Masuda3 , Toshiaki Umezawa4 , Mikio Shimada4 , Naotaka Nagakura5 , Wasuke Kamisako6 , Yoshiki Kashiwada7 , Yasumasa Ikeshiro7
  • 1 Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan
  • 2 Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
  • 3 Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • 4 Institute of Wood Science, Kyoto University, Uji, Kyoto, Japan
  • 5 Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan
  • 6 Mukogawa Women's University, Nishinomiya, Japan
  • 7 Niigata College of Pharmacy, Kamishinei-cho, Niigata, Japan
Further Information

Publication History

March 23, 2000

July 16, 2000

Publication Date:
31 December 2001 (online)

Abstract

Various natural and synthetic compounds including alkaloids, terpenoids and phenolics were tested for inhibition of the cell surface expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), both of which are crucial in the regulation of immune response and inflammation. Of 40 compounds tested, two compounds significantly downregulated the expression of VCAM-1 on murine endothelial cells (F-2) and ten compounds that of ICAM-1 on mouse myeloid leukemia cells (M1). Sanguinarine chloride (5) and isoliquiritigenin (13) were capable of lowering the levels of both ICAM-1 and VCAM-1. The structure-activity relationships study on chalcone and flavone derivatives related to 13 suggested that the inhibitory activity of the chalcone derivatives is attributable to the 4-hydroxy group as well as the possible coplanarity between the phenyl ring and the adjacent conjugated ketone.

Abbreviations

ICAM-1:intercellular adhesion molecule-1

LFA-1:leukocyte function associated antigen-1

VCAM-1:vascular cell adhesion molecule-1

VLA-4:very late antigen-4

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Prof. Dr. S. Tanaka

Department of Bioscience

Tokyo University of Agriculture

1-1-1 Sakuragaoka

Setagaya-ku

Tokyo 156-8502

Japan

Email: stanaka@nodai.ac.jp

Fax: +81 3-5477-2762