Planta Med 2001; 67(2): 189-190
DOI: 10.1055/s-2001-11518
Letter

© Georg Thieme Verlag Stuttgart · New York

Isoquinoline Alkaloids from Thalictrum delavayi

Mai Li, Xin Chen, Qin-Mei Tang, Jin-Sheng Zhang*
  • Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Further Information

Publication History

March 23, 2000

September 10, 2000

Publication Date:
31 December 2001 (online)

Abstract

Two new protoberberine alkaloids, 2,3,9,10-dimethylenedioxy-8-oxoprotoberberine (1) and 2,3,9,10-dimethylenedioxy-1,8-dihydroxyprotoberberine (2), together with nine known isoquinoline-type alkaloids were isolated from the roots of Thalictrum delavayi. Their structures were elucidated by spectral methods. Among these compounds, pseudoprotopine showed competitive inhibition activity by DA receptor binding assay (D1) in vitro. The competitive inhibitions were 87.5 % (10-4 M) and 15.6 % (10-6 M), respectively.

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Prof. Jin-Sheng Zhang

Institute of Materia MedicaShanghai Institutes for Biological Sciences

Chinese Academy of Sciences

294 Tai-Yuan Road

Shanghai 200031

P. R. China

Email: jszhang@mail.shcnc.ac.cn

Fax: +86-21-64370269