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DOI: 10.1055/s-2001-11518
© Georg Thieme Verlag Stuttgart · New York
Isoquinoline Alkaloids from Thalictrum delavayi
Publication History
March 23, 2000
September 10, 2000
Publication Date:
31 December 2001 (online)
![](https://www.thieme-connect.de/media/plantamedica/200102/lookinside/thumbnails/10.1055-s-2001-11518-1.jpg)
Abstract
Two new protoberberine alkaloids, 2,3,9,10-dimethylenedioxy-8-oxoprotoberberine (1) and 2,3,9,10-dimethylenedioxy-1,8-dihydroxyprotoberberine (2), together with nine known isoquinoline-type alkaloids were isolated from the roots of Thalictrum delavayi. Their structures were elucidated by spectral methods. Among these compounds, pseudoprotopine showed competitive inhibition activity by DA receptor binding assay (D1) in vitro. The competitive inhibitions were 87.5 % (10-4 M) and 15.6 % (10-6 M), respectively.
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Prof. Jin-Sheng Zhang
Institute of Materia MedicaShanghai Institutes for Biological Sciences
Chinese Academy of Sciences
294 Tai-Yuan Road
Shanghai 200031
P. R. China
Email: jszhang@mail.shcnc.ac.cn
Fax: +86-21-64370269