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Synthesis 2001(5): 0693-0695
DOI: 10.1055/s-2001-12768
DOI: 10.1055/s-2001-12768
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
Practical One-Step Synthesis of Koga’s Chiral Bases
Further Information
Publication History
Received
13 September 2000
Publication Date:
15 October 2004 (online)
Abstract
A simple, efficient and practical method for the preparation of Koga"s chiral bases is described. The method involves attack of an amine on a styrene oxide-derived aziridinium ion and has allowed the synthesis of novel diamines which cannot be prepared using Koga"s original route.
Key words
amines - chirality - amino alcohols - aziridinium ions