Thorac Cardiovasc Surg 2001; 49(3): 131-136
DOI: 10.1055/s-2001-14287
Original Cardiovascular
Original Paper
© Georg Thieme Verlag Stuttgart · New York

Clinical Use of Heparin-Coated Cardiopulmonary Bypass in Coronary Artery Bypass Grafting[*]

N. Mirow, K. Minami, G. Kleikamp, G. Tenderich, T. Puhlmann, R. Körfer
  • Department of Thoracic and Cardiovascular Surgery, Heart Center NRW, Ruhr University of Bochum, Bad Oeynhausen, Germany
Further Information

Publication History

Publication Date:
31 December 2001 (online)

Clinical handling, risk and benefit of a heparin-coated cardiopulmonary bypass system combined with reduced systemic heparinization in coronary bypass surgery was investigated in a prospective, randomized clinical study. 243 patients (Pts.) were divided into 3 groups: group A (n = 83) had a standard uncoated extracorporeal circulation (ECC) set, and systemic heparin was administered in an initial dose of 400 IE/kg body weight. During ECC activated clotting time (ACT) was kept ≥ 480 sec. Group B (n = 77) had the same ECC set completely coated with low-molecular-weight heparin; i. v. heparin was given in the same dose as in group A, ACT was kept at the same level. Group C (n = 83) had the same coated ECC set as group B, but i. v. heparin was reduced to 150 IE/kg, and was set to be ≥ 240 sec during ECC ACT. The same circulatory components were used in all 3 groups including roller pumps, coronary suction and an open cardiotomy reservoir. In the postoperative clinical course, recovery was not significantly different between groups, especially with respect to organ dysfunction; but there was significantly reduced postoperative bleeding where heparin-coated ECC and low-dose systemic heparinization were both used. This circulatory technique was also associated with a distinctly lower need for postoperative blood replacement. We conclude that heparin-coated extracorporeal circulation combined with either full-dose or reduced systemic heparinization can be used effectively with the same standard equipment and procedures as in uncoated technology. Combination with low-dose i. v. heparin leads to significantly decreased blood loss and less need for blood replacement.

1 Presented at the 3rd Joint Meeting of the German, the Austrian and the Swiss Societies for Thoracic and Cardiovascular Surgery in Lucerne on February 9 - 12, 2000

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1 Presented at the 3rd Joint Meeting of the German, the Austrian and the Swiss Societies for Thoracic and Cardiovascular Surgery in Lucerne on February 9 - 12, 2000

Nikolas MirowM.D. 

Department of Thoracic and Cardiovascular Surgery
Heart Center NRW
Ruhr University of Bochum

Georgstraße 11

32545 Bad Oeynhausen

Germany

Phone: +49-5731-971331

Fax: +49-5731-971300

Email: nmirow@hdz-nrw.ruhr-uni-bochum.de