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Planta Med 2001; 67(4): 366-368
DOI: 10.1055/s-2001-14327
Letter

© Georg Thieme Verlag Stuttgart · New York

Antioxidant Activity of Leaves of Salvia Species in Enzyme-Dependent and Enzyme-Independent Systems of Lipid Peroxidation and their Phenolic Constituents

István Zupkó1 , Judit Hohmann2,*, Dóra Rédei2 , György Falkay1 , Gábor Janicsák3 , Imre Máthé1, 3
  • 1 Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary
  • 2 Department of Pharmacognosy, University of Szeged, Szeged, Hungary
  • 3 Institute of Ecology and Botany of the Hungarian Academy of Sciences, Vácrátót, Hungary
Further Information

Publication History

June 30, 2000

October 8, 2000

Publication Date:
31 December 2001 (online)

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Abstract

The protective effects of eleven Salvia species native to Europe against enzyme-dependent and enzyme-independent lipid peroxidation were evaluated. The 50 % aqueous methanolic extracts of the leaves of all tested plants were found to be more effective than the positive control α-tocopherol acid succinate. The extracts of S. candelabrum, S. ringens, S. tomentosa, S. nemorosa, and S. glutinosa displayed considerable concentration-dependent antioxidative effects that were comparable to those of the medicinal and aromatic plant S. officinalis. The concentrations of flavonoids, hydroxycinnamic acids and total phenolic compounds in each extract were quantified with the aim of clarifying the connection between activity and chemical composition.

References

  • 1 Cuppett S L, Hall C A. Antioxidant activity of the Labiatae.  Advances in Food and Nutrition Research. 1998;  42 245-71
    PubMedSearch in Google Scholar
  • 2 Hohmann J, Zupkó I, Rédei D, Csányi M, Falkay Gy, Máthé I, Janicsák G. Protective effects of the aerial parts of Salvia officinalis, Melissa officinalis and Lavandula angustifolia and their constituents against enzyme-dependent and enzyme-independent lipid peroxidation.  Planta Medica. 1999;  65 576-8
    Thieme ConnectPubMedSearch in Google Scholar
  • 3 Lamaison J L, Petitjean-Freytet C, Carnat A. Lamiacées médicinales á propriétés antioxydantes, sources potentielles d'acide rosmarinique.  Pharmaceutica Acta Helvetiae. 1991;  66 185-8
    PubMedSearch in Google Scholar
  • 4 Cuvelier M E, Berset C, Richard H. Antioxidant constituents in sage (Salvia officinalis).  Journal of Agricultural Food Chemistry. 1994;  42 665-9
    CrossrefPubMedSearch in Google Scholar
  • 5 Wang M, Shao Y, Li J, Zhu N, Rangarajan M, LaVoie E J, Ho C T. Antioxidative phenolic glycosides from sage (Salvia officinalis).  Journal of Natural Products. 1999;  62 454-6
    CrossrefPubMedSearch in Google Scholar
  • 6 Dugas A J, Castaneda-Acosta J, Bonin G C, Price K L, Fischer N H, Winston G W. Evaluation of the total peroxyl radical-scavanging capacity of flavonoids: Structure-activity relationships.  Journal of Natural Products. 2000;  63 327-31
    CrossrefPubMedSearch in Google Scholar
  • 7 Mabry T J, Markham K R, Thomas M B. The Systematic Identification of Flavonoids. Berlin, Heidelberg, New York; Springer 1970: 95-96 and 285 - 6
  • 8 Stocks J, Gutteridge J MC, Sharp R J, Dormandy T L. Assay using brain homogenate for measuring the antioxidant activity of biological fluids.  Clinical Science and Molecular Medicine. 1974;  47 215-22
    PubMedSearch in Google Scholar
  • 9 Engineer F N, Sridhar R. Attenuation of daunorubicin-augmentol microsomal lipid peroxidation and oxygen consumption by calcium channal antagonists.  Biochemical and Biophysical Research Communications. 1991;  179 1101-6
    CrossrefPubMedSearch in Google Scholar

Dr. Judit Hohmann

Department of Pharmacognosy

University of Szeged

P.O. Box 121

6701 Szeged

Hungary

Email: hohmann@pharma.szote.u-szeged.hu

Fax: +(36)62 545 704