Zusammenfassung
Paroxysmale Phänomene sind nicht so seltene und recht typische klinische Manifestationen der multiplen Sklerose. Diese Sekunden oder wenige Minuten dauernden Ausfalls- oder Reizerscheinungen von Seiten verschiedener Bereiche im ZNS lassen sich am ehesten durch ephaptische Impulsübertragung infolge myelino-axonaler Dissoziation innerhalb der MS-Plaque erklären. Sie sollten deshalb erkannt werden, weil sie auch bereits als Initialsymptome der Krankheit vorkommen können, für die Betroffenen sehr unangenehm sind und oft auf eine Behandlung mit Antiepileptika gut ansprechen.
Paroxysmal Phenomena in Multiple Sclerosis
Paroxysmal phenomena are rare but relatively typical clinical symptoms of multiple sclerosis which may occasionally occur as initial manifestation of the disease. Such shortlived clinical symptoms and signs are probably caused by ephaptic impulse transmission due to myelino-axonal dissociation within the demyelinated plaque. They should be recognized since they can serve as clinical indicators of the disease and can be treated efficiently with antiepileptic drugs.
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Prof. Jürg Kesselring
Chefarzt Neurologie
Rehabilitationszentrum
7317 Valens
Schweiz
eMail: kesselring.klival@spin.ch
