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DOI: 10.1055/s-2001-15852
Recurrent Crohn's Disease
Publication History
Publication Date:
31 December 2001 (online)
ABSTRACT
Persons afflicted with Crohn's disease are beset by the likelihood of recurrence following resection of their disease. In an effort to better counsel patients about their relative risk, many centers have evaluated myriad factors thought to herald recurrence. Insightful review of the literature requires consideration of the definition of recurrence, length and manner of follow-up, and statistical tools used for analysis of the data. Factors that may possibly influence recurrence include age of disease onset, gender, tobacco use, anatomic pattern of disease, clinical pattern of disease, duration of preoperative symptoms, previous resections, blood transfusion, extent of resection, pathological features of resected bowel, and chemotherapy following resection. Unfortunately, the individual or collective role that these factors play in disease recurrence remains poorly understood.
KEYWORD
Crohn's disease - recurrence - cumulative rate - multivariate analysis - resection - strictureplasty
REFERENCES
- 1 Crohn B B, Ginzburg L, Oppenheimer G D. Regional ileitis. JAMA . 1932; 99 214-220
- 2 Bernell O, Lapidus A, Hellers G. Risk factors for surgery and postoperative recurrence in Crohn's disease. Ann Surg . 2000; 231 38-45
- 3 Strong S A. Prognostic parameters of Crohn's disease recurrence. Clin Gastroenterol . 1998; 12 167-178
- 4 de Jong E, van Dullemen M H, Slors J F. Correlation between early recurrence and reoperation after ileocolonic resection in Crohn's disease: a prospective study. J Am Coll Surg . 1996; 182 503-508
- 5 Rutgeerts P, Geboes K, Vantrappen G. Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery. Gut . 1984; 25 665-672
- 6 Michelassi F, Balestracci T, Chappell R. Primary and recurrent Crohn's disease. Experience with 1379 patients. Ann Surg . 1991; 214 230-238
- 7 Heimann T M, Greenstein A J, Lewis B. Prediction of early symptomatic recurrence after intestinal resection in Crohn's disease. Ann Surg . 1993; 218 294-298
- 8 Cottone M, Rosselli M, Orlando A. Smoking habits and recurrence in Crohn's disease. Gastroenterology . 1994; 106 643-648
- 9 Silvis R, Steup W H, Brand A. Protective effect of blood transfusion on postoperative recurrence of Crohn's disease in parous women. Transfusion . 1994; 34 242-247
- 10 Holzheimer R G, Molloy R G, Wittmann D H. Postoperative complications predict recurrence of Crohn's disease. Eur J Surg . 1995; 161 129-135
- 11 Aeberhard P, Berchtold W, Riedtmann H J. Surgical recurrence of perforating and nonperforating Crohn's disease. A study of 101 surgically treated patients. Dis Col Rectum . 1996; 39 80-87
- 12 Caprilli R, Corrao G, Taddei G. Prognostic factors for postoperative recurrence of Crohn's disease. Gruppo Italiano per lo Studio del Colon e del Retto (GISC). Dis Col Rectum . 1996; 39 335-341
- 13 Raab Y, Bergstrom R, Ejerblad S. Factors influencing recurrence in Crohn's disease. An analysis of a consecutive series of 353 patients treated with primary surgery. Dis Col Rectum . 1996; 39 918-925
- 14 Anseline P F, Wlodarczyk J, Murugasu R. Presence of granulomas is associated with recurrence after surgery for Crohn's disease: experience of a surgical unit. Br J Surg . 1997; 84 78-82
- 15 Lautenbach E, Berlin J A, Lichtenstein G R. Risk factors for early postoperative recurrence of Crohn's disease. Gastroenterology . 1998; 115 259-267
- 16 Moskovitz D, McLeod R S, Greenberg G R, Cohen Z. Operative and environmental risk factors for recurrence of Crohn's disease. Int J Colorectal Dis . 1999; 14 224-226
- 17 Yamamoto T, Keighley M R. Smoking and disease recurrence after operation for Crohn's disease. Br J Surg . 2000; 87 398-404
- 18 Farmer R G, Hawk W A, Turnbull R B. Clinical patterns in Crohn's disease: a statistical study of 615 cases. Gastroenterology . 1975; 68 627-635
- 19 Nordgren S R, Fasth S B, Oresland T O. Long-term follow-up in Crohn's disease. Mortality, morbidity, and functional status. Scand J Gastroenterol . 1994; 29 1122-1128
- 20 Greenstein A J, Lachman P, Sachar D B. Perforating and nonperforating indications for repeated operations in Crohn's disease: evidence for two clinical forms. Gut . 1988; 29 588-592
- 21 Sachar D B, Subramani K, Mauer K. Patterns of postoperative recurrence in fistulizing and stenotic Crohn's disease: a retrospective cohort study of 71 patients. J Clin Gastroenterol . 1996; 22 114-116
- 22 Yamamoto T, Allan R N, Keighley M R. Perforating ileocecal Crohn's disease does not carry a high risk of recurrence but usually re-presents as perforating disease. Dis Col Rectum . 1999; 42 519-524
- 23 Williams J G, Wong W D, Rothenberger D A. Recurrence of Crohn's disease after resection. Br J Surg . 1991; 78 10-19
- 24 Cristaldi M, Sampietro G M, Danelli P G. Long-term results and multivariate analysis of prognostic factors in 138 consecutive patients operated on for Crohn's disease using ``bowel-sparing'' techniques. Am J Surg . 2000; 179 266-270
- 25 Griffiths A M, Wesson D E, Shandling B. Factors influencing recurrence of Crohn's disease in childhood. Gut . 1991; 32 491-495
- 26 Steup W H, Brand A, Weterman I T. The effect of perioperative blood transfusion on recurrence after primary operation for Crohn's disease. Scand J Gastroenterol . 1991; 188 81-86
- 27 Wettergren A, Christiansen J. Risk of recurrence and reoperation after resection for ileocolic Crohn's disease. Scand J Gastroenterol . 1991; 26 1319-1322
- 28 Kim N K, Senagore A J, Luchtefeld M A. Long-term outcome after ileocecal resection for Crohn's disease. Am Surg . 1997; 63 627-633
- 29 Scott A D, Ritchie J K, Phillips R K. Blood transfusion and recurrent Crohn's disease. Br J Surg . 1991; 78 455-458
- 30 Hollaar G L, Gooszen H G, Post S. Perioperative blood tranfusion does not prevent recurrence in Crohn's disease. A pooled analysis. J Clin Gastroenterol . 1995; 21 134-138
- 31 D'Haens G R, Gasparaitas A E, Hanauer S B. Duration of recurrent ileitis after ileocolonic resection correlates with presurgical extent of Crohn's disease. Gut . 1995; 36 715-717
- 32 Fazio V W, Marchetti F, Church J M. Effect of resection margins on the recurrence of Crohn's disease in the small bowel. A randomized controlled trial. Ann Surg . 1996; 224 563-571
- 33 Cameron J L, Hamilton S R, Coleman J. Patterns of ileal recurrence in Crohn's disease. A prospective randomized study. Ann Surg . 1992; 215 546-551
- 34 Kusunoki M, Ikeuchi H, Yanagi H. A comparison of stapled and hand-sewn anastomoses in Crohn's disease. Dig Surg . 1998; 15 679-682
- 35 Hashemi M, Novell J R, Lewis A A. Side-to-side stapled anastomosis may delay recurrence in Crohn's disease. Dis Col Rectum . 1998; 41 1293-1296
- 36 Yamamoto T, Bain I M, Mylonakis E. Stapled functional end-to-end anastomosis versus sutured end-to-end anastomosis after ileocolonic resection in Crohn disease. Scand J Gastroenterol . 1999; 34 708-713
- 37 Prabhakar L P, Laramee C, Nelson H. Avoiding a stoma: role for segmental or abdominal colectomy in Crohn's colitis. Dis Col Rectum . 1997; 40 71-78
- 38 Makowiec F, Paczulla D, Schmidtke C, Starlinger M. Long-term follow-up after resectional surgery in patients with Crohn's disease involving the colon. Zeitschrift Gastroenterol . 1998; 36 619-624
- 39 Stebbing J F, Jewell D P, Kettlewell M G. Long-term results of recurrence and reoperation after strictureplasty for obstructive Crohn's disease. Br J Surg . 1995; 82 1471-1474
- 40 Ozuner G, Fazio V W, Lavery I C. Reoperative rates for Crohn's disease following strictureplasty. Long-term analysis. Dis Col Rectum . 1996; 39 1199-1203
- 41 Tichansky D, Cagir B, Yoo E. Strictureplasty for Crohn's disease: meta-analysis. Dis Col Rectum . 2000; 43 911-919