Planta Med 2001; 67(6): 559-561
DOI: 10.1055/s-2001-16480
Letter

© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Neolignans and Butanolides from Machilus obovatifolia

Ian-Lih Tsai1,*, Jyh-Huey Chen1 , Chang-Yih Duh2 , Ih-Sheng Chen1
  • 1 Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
  • 2 Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, R.O.C.
Further Information

Publication History

August 9, 2000

December 7, 2000

Publication Date:
17 August 2001 (online)

Abstract

From the chloroform-soluble portion of the stem wood of Machilus obovatifolia, one new neolignan, perseal F (1), four known neolignans, perseal G (2), licarin A, licarin B, acuminatin, two butanolides, linderanolide E and isolinderanolide E, two steroids, β-sitosterol, β-sitosterol-β-D-glucoside, and syringaldehyde were isolated. Perseal F (1) and G (2) are neolignans that have a C-1′ formyl side chain instead of a propenyl group. Compound 2 was isolated in a mixture with acuminatin. The structure of 2 was identified by comparison with the product formed by the Lemieux-von Rudloff oxidation of licarin B. Two minor oxidative by-products, 2a and 2b, were also obtained. Linderanolide E showed cytotoxicities against P-388, KB16, A549 and HT-29, 1 against P-388, KB16 and HT-29, and isolinderanolide E against P-388, cancer cell lines, respectively. All structures were identified by means of spectroscopic analyses.

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Prof. Dr. Ian-Lih Tsai

School of Pharmacy

College of Pharmacy

Kaohsiung Medical University

Kaohsiung

Taiwan, R.O.C.

Email: ialits@kmu.edu.tw

Fax: +886-7-321-0683