Zusammenfassung.
Das Nierenzellkarzinom führt häufig zu Spätmetastasen, die charakteristischerweise Jahre nach dem Primärtumor oft in ungewöhnlichen Lokalisationen auftreten. Nur selten handelt es sich hierbei um Solitärmetastasen, die einer chirurgischen Therapie zugänglich sind. Es werden zwei Patienten mit solitären Spätmetastasen im Pankreas 20 beziehungsweise 25 Jahre nach Nephrektomie wegen eines Nierenzellkarzinoms sowie eine Patientin mit einer solitären Spätmetastase in der Milz 25 Jahre nach Nephrektomie dargestellt, die durch Pankreasresektion beziehungsweise Splenektomie behandelt wurden.
Surgical therapy of isolated late renal all carcinoma late metastasis in spleen and pancreas.
Renal carcinoma often leads to late metastases which typically appear years after the primary tumour often in unusual localisations. Only rarely they are solitary metastases which can be treated surgically. Two patients are presented with late solitary metastases in the pancreas respectively 20 and 25 years after nephrectomy for renal carcinoma, and one patient with a late solitary metastasis in the spleen 25 years after nephrectomy. They were treated by pancreas resection or splenectomy.
Schlüsselwörter:
Nierenzellkarzinom - Pankreasmetastasen - Milzmetastasen
Key Words:
Renal carcinoma - Pancreatic metastases - Splenic metastases
Literatur
-
1
Mc Nichols D W, Seguar J W, DeWeerd J H.
Renal cell carcinoma: long-term survical and late recurrence.
J Urol.
1981;
126
17-23
-
2
Ritchie A W, Chisholm G D.
The natural history of renal carcinoma.
Semin Oncol.
1983;
10
390-400
-
3 Willis R A. The spread of tumors in the human body. New York; Butterworth 1975: 216
-
4
Butturini G, Bassi C, Falconi M, et al.
Surgical treatment of pancreatic metastases from renal cell carcinomas.
Dig Surg.
1998;
15
241-246
-
5
Fabre J M, Rouanet P, Dagues F, Blanc F, et al.
Various features and surgical approach of solitary pancreatic metastasis from renal cell carcinoma.
Eur J Surg Oncol.
1995;
21
683-686
-
6
Fricke P, Schulz H-U, Buhtz P, Lippert H.
Multiple metachrone Metastasen eines Nierenzellcarcinoms im Pankreas.
Chirurg.
2000;
71
575-579
-
7
Hashimoto M, Watanabe G, Matsuda M, Dohi T, Tsumaru M.
Management of the pancreatic metastases from renal cell carcinoma: report of four resected cases.
Hepatogastroenterology.
1998;
45
1150-1154
-
8
Hirota T, Tomida T, Iwasa M, et al.
Solitary pancreatic metastasis occuring eight years after nephrectomy for renal cell carcinoma. A case report and surgical review.
Int J Pancreatol.
1996;
19
145-153
-
9
Jingu K, Watanabe K, Yamamoto H, et al.
Surgical treatment of a solitary pancreatic metastasis from renal cell carcinoma: report of a case.
Surg Today.
1998;
28
91-94
-
10
Robbins E G, Franceschi D, Barkin J S.
Solitary metastatic tumors to the pancreas: a case report and review of the literature.
Am J Gastroenterol.
1996;
91
2414-2417
-
11
Stankard C E, Karl R C.
The treatment of isolated pancreatic metastases from renal cell carcinoma: a surgical review.
Am J Gastroenterol.
1992;
87
1658-1660
-
12
Temellini F, Bavosi M, Lamarra M, Quagliarini P, Giuliani F.
Pancreatic metastasis 25 years after nephrectomy for renal cancer.
Tumori.
1989;
75
503-504
-
13
Vergara V, Marucci M, Marcarino C, Brunello F, Capussotti L.
Metastatic involvement of the pancreas from renal cell carcinoma treated by surgery.
Ital J Gastroenterol.
1993;
25
388-390
-
14
Zraggen K, Fernandez-del Castillo C, Rattner D W, Sigala H, Warshaw A L.
Metastases to the pancreas and their surgical extirpation.
Arch Surg.
1998;
133
413-418
-
15
Zugel N, Leipprand E, Weckermann D, Witte J.
Solitäre Pankreaskopfmetastase bei hypernephroidem Karzinom.
Fortschr Med.
1994;
112
388-390
-
16
Ishida H, Konno K, Ishida J, et al.
Isolated splenic metastases.
J Ultrasound Med.
1997;
16
743-749
-
17
Tongaonkar H B, Kulkarm J N, Kamat M R.
Solitary metastases from renal cell carcinoma: a review.
J Surg Oncol.
1992;
49
45-48
-
18
Klugo R C, Detmers M, Stiles R E, Talley R W, Cerny J C.
Aggressive versus conservative management of stage IV renal cell carcinoma.
J Urol.
1997;
118
244-246
-
19
Roland C F, van Heerden J A.
Non-pancreatic primary tumors with metastasis to the pancreas.
J Surg Oncol Obstet.
1989;
168
345-347
-
20
Klein B, Stein M, Kuten A, et al.
Splenomegaly and solitary spleen metastasis in solid tumors.
Cancer.
1987;
60
100-102
-
21
Berge T.
Splenic metastases: frequencies and patterns.
Acta Pathol Microbiol Scand.
1974;
82
499-506
-
22
Wernecke K, Peters P E, Galanski M.
Pancreatic metastases: US evaluation.
Radiology.
1986;
160
399-402
-
23
Kanai T, Aoki A, Okazeri S, et al.
Successful aggressive treatment against multiple intra-abdominal metastases from renal cell carcinoma 18 years after nephrektomy.
Jpn J Clin Oncol.
1992;
22
216-220
Dr. med. Cornelia Leszinski
Stadtkrankenhaus Worms
Chirurgische Klinik I
Gabriel-von-Seidl-Straße 81
67550 Worms
