Oxidation of D-[U -¹⁴C] Glucose and [1,12 -¹⁴C] Dodecanedioic Acid by Pancreatic Islets from Goto-Kakizaki Rats

In pancreatic islets from hereditarily diabetic GK rats, [1,12 -¹⁴C] dodecanedioic acid (5.0 mM) was oxidized at a rate representing about 5 % of that of D-[U - ¹⁴C] glucose (8.3 mM). Dioic acid and hexose failed to exert any significant reciprocal effects on their respective oxidation. The production of ¹⁴CO₂ from [1,12 -¹⁴C] dodecanedioic acid was proportional to its concentration in the 0.2 - 5.0 mM range. These results were essentially comparable to those obtained in islets from control rats. They extend, therefore, to GK rats the knowledge that dodecanedioic acid acts as a nutrient in pancreatic islet cells.

Key words:

 [1,12 -¹⁴C] Dodecanedioic Acid - Pancreatic Islets - GK Rats

References

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