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DOI: 10.1055/s-2001-17110
Gezielte Modulation des Immunsystems mit CpG-Oligonukleotiden
Specific modification of the immune system with CpG-oligonucleotidesPublikationsverlauf
Publikationsdatum:
13. September 2001 (online)

Bei der Untersuchung von B-Zellen nach In-vivo-Stimulation mit Antisense-Oligonukleotiden beobachtete Arthur Krieg eine unspezifische Steigerung der Proliferation muriner B-Zellen durch eines seiner Kontroll-Oligonukleotide. Er fand heraus, dass dieser Effekt von einem zentralen Cytidin-Guanosin-Dinukleo-tid (CpG; p: phosphat) abhängt und definierte das aktive »CpG-Motiv« als eine Abfolge von sechs Basen (z.B. bei der Maus: 5′...Purin Purin C G Pyrimidin Pyrimidin...3′) [13].
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Dr. med. Anne Krug
Dr. med. Gunther Hartmann
Abteilung für Klinische Pharmakologie, (Leiter:
Prof. Dr. med. Stefan Endres, Medizinische Innenstadt, (Komm.
Direktor: Prof. Dr. med. Detlef Schlöndorff, Klinikum
der Universität München
Ziemssenstraße 1
80336 München
Telefon: 089/5160-2331
Fax: 089/5160-4406
eMail: ghartmann@lrz.uni-muenchen.de