Bovine Hemoglobin (HBOC-201)
Restores Tissue Oxygen Tension During Peripheral and Coronary
Artery Stenosis under Extended
Hemodilution

Hemoglobins - Oxygen Carrier - Acute Arterial Stenosis - Poststenotic Oxygenation

References

• 1 Feola M, Gonzalez H, Canizaro P C, Bingham D, Periman P. Development of a bovine stroma-free hemoglobin solution as a blood substitute. Surg Gynecol Obstet 1983 157: 399-408
• 2 Standl T, Reeker W, Redmann G, Kochs E, Werner C, Schulte am Esch J. Haemodynamic changes and skeletal muscle oxygen tension during complete blood exchange with ultrapurified polymerized bovine haemoglobin. Intensive Care Med 1997 23: 865-872
• 3 Manning J M. Random chemical modification of hemoglobin to identify chloride binding sites in the central dyad axis: their role in control of oxygen affinity. Artif Cells Blood Substit Immobil Biotechnol 1994 22: 199-205
• 4 Standl T, Horn E P, Wilhelm S, Greim C, Freitag M, Freitag U, Sputtek A, Jacobs E E, Schulte am Esch J. Bovine haemoglobin is more potent than autologous red blood cells in restoring muscular tissue oxygenation after profound isovolaemic haemodilution in dogs. Can J Anesthesiol 1996 43: 714-723
• 5 Horn E -P, Standl T, Burmeister M A, Bangert K, Gottschalk A, Schulte am Esch J. Additional Augmentation of Liver Tissue Oxygen Tension Following Hemodilution With Bovine Hemoglobin. Anesth Analg 2000 90: S 427
• 6 Hughes GS J r, Yancey E P, Albrecht R, Locker P K, Francom S F, Orringer E P, Antal E J, Jacobs E E. Hemoglobin-based oxygen carrier preserves submaximal exercise capacity in humans. Clin Pharmacol Ther 1995 58: 434-443
• 7 Kasper S M, Walter M, Grune F, Bischoff A, Erasmi H, Buzello W. Effects of a hemoglobin-based oxygen carrier (HBOC-201) on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery. Anesth Analg 1996 83: 921-927
• 8 Standl T, Wilhelm S, Horn E P, Burmeister M, Gundlach M, Schulte am Esch J. Preoperative hemodilution with bovine hemoglobin. Acute hemodynamic effects in liver surgery patients. Anaesthesist 1997 46: 763-770
• 9 Horn E P, Standl T, Wilhelm S, Jacobs E E, Freitag U, Freitag M, Schulte am Esch J. Bovine Surgery Hemoglobin Increases Skeletal Muscle Oxygenation During 95% Artificial Arterial Stenosis. Surgery 1997 121: 411-419
• 10 Borgia J F, Horvath S M, Sorich R A. Persistent myocardial ischemia following chronic hyperoxia in conscious dogs. J Thorac Cardiovasc Surg 1983 86: 710-717
• 11 Habler O, Kleen M, Pape A, Meisner F, Kemming G, Messmer K. Diaspirin-crosslinked hemoglobin reduces mortality of severe hemorrhagic shock in pigs with critical coronary stenosis. Crit Care Med 2000 28: 1889-1898
• 12 Standl T, Horn E -P, Burmeister M A, Bangert K, Reiter B, Jacobs E E, Schulte am Esch J. Bovine Hemoglobine Restores Myocardial Tissue Oxygen Tension in Dogs With Acute Critical Coronary Stenosis and Extended Hemodilution.  Anesthesiology 1999 91: A 697
• 13 Bangert K, Burmeister M A, Horn E -P, Standl T, Schulte am Esch J. HBOC-201 verbessert das myocardiale Kontraktionsverhalten unter Anämie im Koronarstenosemodell beim Hund. AINS 2000 35: S 481
• 14 Burmeister M, Bangert K, Horn E -P, Arnold G, Standl T, Schulte am Esch J. Prophylaxe mit bovinem Hämoglobin reduziert den myocardialen TPO2-Abfall und die Myocardschäden unter akuter Koronarstenose im Tierexperiment. AINS 2001 42: S 473