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Planta Med 2001; 67(8): 700-704
DOI: 10.1055/s-2001-18349
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Antiproliferative, Anti-Aromatase, Anti-17β-HSD and Antioxidant Activities of Lignans Isolated from Myristica argentea

F. Filleur, J.C. Le Bail, J. L. Duroux, A. Simon, A.J. Chulia*
  • UPRES EA 1085, Biomolécules et cibles cellulaires tumorales, UFR de Pharmacie, Limoges, France
Further Information

Publication History

November 13, 2000

February 18, 2001

Publication Date:
09 November 2001 (online)

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Abstract

Four lignans were isolated from the petrol extract of Myristica argentea mace (Myristicaceae) and their structures were elucidated by means of NMR and mass spectrometry. Although they have been previously described, NMR data are only available for threo-austrobailignan-5, which has been isolated only once, and is incomplete. Three of them, erythro-austrobailignan-6, meso-dihydroguaiaretic acid and nectandrin-B, exert an antiproliferative effect on MCF-7 cells as well as antioxidant activity on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, but not the threo-austrobailignan-5. Nectandrin-B also possesses anti-17β-hydroxysteroid dehydrogenase and anti-aromatase activities.

Key words

Myristica argentea - Myristicaceae - lignans - antiproliferative activity - antioxidant activity - anti-17β-HSD activity - anti-aromatase activity

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Prof. A. J. Chulia

Laboratoire de Pharmacognosie

UPRES EA 1085

UFR de Pharmacie

 2 rue du docteur Marcland

 87025 Limoges

France

Fax: +33 05 55 43 59 10

Email: jose.chulia@unilim.fr