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Osteosynthesis and Trauma Care 2001; 9(4): 173-175
DOI: 10.1055/s-2001-20198
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© Georg Thieme Verlag Stuttgart · New York

Native bovine BMP in the treatment of ulnar pseudoarthrosis

A case reportKnochenaufbauendes Protein (BMP) in der Behandlung von UlnarpseudarthrosenEin FallberichtT. Tuominen1 , T.  Raatikainen2 , J. Leppilahti2 , P. Jalovaara1 , 2
  • 1Bone Transplantation Research Group, University of Oulu, Oulu, Finland
  • 2Department of Orthopaedic Surgery, Oulu University Hospital, Oulu, Finland
Further Information

Publication History

Publication Date:
19 February 2002 (online)

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Summary

Ten years old intactable ulnar non-union of a 28-year-old woman was treated with a composite graft of biocoral, collagen and native bovine bone morphogenetic protein. A complete union was achieved.

Knochenaufbauendes Protein (BMP) in der Behandlung von Ulnarpseudarthrosen. Ein Fallbericht

Zusammenfassung

Die chronische Pseudarthrose der Ulna einer 28jährigen Frau wurde mit einem Kombinationstransplantat aus Kollagen, Naturkorall und native bovine Bone morphogenetischem Protein mit gutem Ergebnis behandelt.

Résumé

La patiente (28 ans) souffrante d'une pseudoarthrose du cubitus a été traitée avec succès par un implant combinée (collagène, corail natural et protéines).

Resumen

BMP (Proteína morfogenética ósea) bovina en el tratamiento de la pseudoartrosis de cúbito. Sobre un caso.

Key words

Bone morphogenetic protein - non-union - ulnar pseudoarthrosis

Schlüsselwörter

Knochenaufbauendes Protein - Pseudarthrose - Ulnapseudarthrose

Mots clés

Collagène - corail natural et protéines - pseudoarthrosis - ulnar pseudoarthrosis

Palabras claves

Proteína morfogenética ósea - pseudoartrosis - pseudoartrosis de cúbito

References

  • 1 Boden S D, Zdeblick T A, Sandhu H S, Heim S E. The use of rhBMP-2 in interbody fusion cages.  Spine. 2000;  25 376-381
    CrossrefPubMedSearch in Google Scholar
  • 2 Boyne P J, Marx R E, Nevins M, Triplett G, Lazaro E, Lilly L C, Alder M, Nummikoski P. A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation.  Int J Periodontitics Restorative Dent. 1997;  17 11-25
    PubMedSearch in Google Scholar
  • 3 Cook S D, Baffes G C, Wolfe M W, Sampath T K, Rueger D C, Whitecloud T S. The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects.  J Bone Joint Surg [Am]. 1994;  76 827-838
    PubMedSearch in Google Scholar
  • 4 Cook S D, Wolfe M W, Salkeld  S L, Rueger D C. Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates.  J Bone Joint Surg [Am]. 1995;  77 734-750
    PubMedSearch in Google Scholar
  • 5 Elsinger E C, Leal L. Coralline hydroxyapatite bone graft substitutes.  J Foot Ankle Surg. 1996;  35 396-399
    PubMedSearch in Google Scholar
  • 6 Gao T J , Lindholm T S, Marttinen A, Puolakka T. Bone inductive potential and dose-dependent response of bovine bone morphogenetic protein combined with type IV collagen carrier.  Ann Chir Gynaecol. 1993;  82 77-84
    PubMedSearch in Google Scholar
  • 7 Geesink R GT, Hoefnagels N HM, Bulstra S K. Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect .  J Bone Joint Surg [Br]. 1999;  81 710-718
    PubMedSearch in Google Scholar
  • 8 Groeneweld E HJ, Burger E H. Bone morphogenetic proteins in human bone regeneration.  Eur J Endocrinol. 2000;  142 9-21
    CrossrefPubMedSearch in Google Scholar
  • 9 Holmes R, Mooney V, Bucholz R, Tencer A. A coralline hydroxyapatite bone graft substitute.  Clin Orthop. 1984;  188 252-262
    PubMedSearch in Google Scholar
  • 10 Howell T H, Fiorellini J, Jones A , Alder M, Nummikoski P, Lazaro M, Lilly L, Cochran D. A feasibility study evaluating rhBMP-2/absorbable collagen sponge device for local alveolar ridge preservation or augmentation.  Int J Periodontics Restorative Dent. 1997;  17 125-139
    PubMedSearch in Google Scholar
  • 11 Johnson E E, Urist M R, Finerman G AM. Resistant nonunions and partial or complete segmental defects of long bones.  Clin Orthop. 1990;  277 229- 237
    PubMedSearch in Google Scholar
  • 12 Johnson E E, Urist M R . Human bone morphogenetic protein allografting for reconstruction of femoral nonunion.  Clin Orthop. 2000;  371 61-74
    PubMedSearch in Google Scholar
  • 13 Kirker-Head C A, Gerhart T N, Armstrong R, Schelling S H, Carmel L A. Healing bone using recombinant human bone morphogenetic protein 2 and copolymer.  Clin Orthop. 1998;  349 205-217
    PubMedSearch in Google Scholar
  • 14 Lane J M, Yasko A W, Tomin E, Cole B J, Waller S, Browne M, Turek T, Gross J. Bone marrow and recombinant human bone morphogenetic protein-2 in osseous repair.  Clin Orthop. 1999;  361 216-227
    PubMedSearch in Google Scholar
  • 15 Sciadini M F, Dawson J M, Johnson K D. Evaluation of bovine-derived bone protein with a natural coral carrier as a bone-graft substitute in a canine segmental defect model.  J Orthop Res. 1997;  15 844-857
    CrossrefPubMedSearch in Google Scholar
  • 16 Yasko A W, Lane J M, Fellinger E J, Rosen V, Wozney  J M, Wang E A. The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2).  J Bone Joint Surg [Am]. 1992;  74 5659-5670
    PubMedSearch in Google Scholar

Pekka  JalovaaraM.D., PhD 

Department of Orthopaedic Surgery

University of Oulu

P.O. Box 50 00

90014 University of Oulu

Finland

Phone: + 3 58-8/3 15 20 11

Fax: + 3 58-8/3 15 53 18

Email: Pekka.Jalovaara@oulu.fi