7-Alkyl Indole Synthesis via a Convenient Formation/Alkylation of Lithionitrobenzenes and an Improved Bartoli Reaction

Abstract

A more convenient and efficient method for metalation/alkylation of nitrobenzenes to give 2-substituted nitrobenzenes was developed. Their conversion to 7-alkylindoles using the Bartoli reaction with vinyl magnesium bromide was performed with an improved protocol.

nitroarenes - lithiation - allylations - alkylations

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