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Synthesis 2002(3): 0403-0408
DOI: 10.1055/s-2002-20044
DOI: 10.1055/s-2002-20044
PAPER
© Georg Thieme Verlag Stuttgart · New York
New Regioselective Synthesis of 7H-Imidazo[2,1-b][1,3]thiazine and 2H,6H-Pyrimido[2,1-b][1,3]thiazine Derivatives.
Further Information
Received
2 January 2002
Publication Date:
28 July 2004 (online)
Publication History
Publication Date:
28 July 2004 (online)
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Abstract
A series of the title compounds were prepared by the reaction of amidines 2 with α-bromoketones, acid chlorides or acrylic dienophiles. The four steps synthesis reaction from thiourea and full characterisation of 7H-imidazo[2,1-b][1,3]thiazines 4, 2H,6H-pyrimido[2,1-b][1,3]thiazin-6-ones 5, and 2H,6H-pyrimido[2,1-b][1,3]thiazines 6 are described.
Key words
bicyclic compounds - heterocycles - alkylations - acylations - Diels-Alder reactions
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