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Planta Med 2002; 68(1): 72-73
DOI: 10.1055/s-2002-20048
DOI: 10.1055/s-2002-20048
Letter
© Georg Thieme Verlag Stuttgart · New York
Iridoids with Anti-Inflammatory Activity from Vitex peduncularis
Further Information
Publication History
February 9, 2001
May 13, 2001
Publication Date:
31 January 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200201/lookinside/thumbnails/10.1055-s-2002-20048-1.jpg)
Abstract
A new iridoid, pedunculariside, together with the known iridoid agnuside were isolated from the butanol extract of Vitex peduncularis stem bark. Both pedunculariside and agnuside showed preferential inhibition of COX-2, with IC50 values of 0.15 ± 0.21 mg/ml and 0.026 ± 0.015 mg/ml respectively, while having only small inhibitory effects on COX-1. Both compounds did not exhibit cytotoxicity against vero cells.
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Prof. Dr. Assoc. A. Suksamrarn
Department of Chemistry
Faculty of Science
Ramkhamhaeng University
Bangkok 10240
Thailand
Email: apichart@ram1.ru.ac.th
Fax: +66 2-3108381