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Planta Med 2002; 68(1): 84-85
DOI: 10.1055/s-2002-20056
Letter

© Georg Thieme Verlag Stuttgart · New York

Monoamine Oxidase Inhibitory Coumarin from Zanthoxylum schinifolium

Young Su Jo1 , Dang Thi Lan Huong1 , KiHwan Bae1 , Myung Koo Lee2 , Young Ho Kim1
  • 11 College of Pharmacy, Chungnam National University, Daejeon, Korea
  • 22 College of Pharmacy, Chungbuk National University, Cheongju, Korea
Further Information

Publication History

January 8, 2001

June 17, 2001

Publication Date:
31 January 2002 (online)

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Abstract

A methanol extract of Zanthoxylum schinifolium stems at a concentration of 250 μg/ml showed potent inhibitory activity against monoamine oxidase (MAO) in a mouse brain. Activity-guided separation and purification of the extract yielded lacinartin (1) as an active coumarin compound. Lacinartin showed significant inhibitory effects on MAO in a dose-dependent manner. The IC50 value on MAO activity was 9.2μM. The MAO-A (IC50 value, 5.7 μM) sensitivity to lacinartin was greater than that of MAO-B (IC50 value, 28.6μM). An enzyme kinetic study revealed that lacinartin inhibited MAO activity by a non-competitive mode.

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Young Ho Kim

College of Pharmacy

Chungnam National University

Daejeon, 305-764

Korea

Email: yhk@cnu.ac.kr

Phone: +82-42-821-5933

Fax: +82-42-823-6566