Thorac Cardiovasc Surg 2002; 50(1): 59-61
DOI: 10.1055/s-2002-20154
Case Report
© Georg Thieme Verlag Stuttgart · New York

Coexistence of Non-Hodgkin’s Lymphoma and Non-Small-Cell Lung Carcinoma: Diagnosis and Treatment

M.  Rothenburger1 , M.  Semik1 , A.  Hoffmeier1 , H.  Baba2 , D.  Kamanabrou3 , N.  Roos4 , C.  Schmidt5 , H.  H.  Scheld1
  • 1Department of Cardiothoracic Surgery, University of Muenster, Germany,
  • 2Gerhard Domagk Institute for Pathology, University of Muenster, Germany,
  • 3Department of Dermatology and Reconstructive Surgery, Fachklinik Hornheide, Muenster, Germany,
  • 4Institute of Clinical Radiology, University of Muenster, Germany,
  • 5Department of Anesthesiology and Operative Intensive Care Medicine, University of Muenster, Germany,
Further Information

Publication History

April 19, 2001

Publication Date:
15 February 2002 (online)

Abstract

In this communication, we will present a very rare case of the coexistence of non-Hodgkin’s lymphoma (NHL; low malignant lymphocytic lymphoma of the B-cell type) and a non-small-cell lung carcinoma (NSCLC). A patient with a 15-year history of NHL developed a generalized relapse of the lymphoma with an additional tumor mass in the left lower lobe of the lung. Bronchoscopy showed the evidence of the NHL. Due to non-responding chemotherapy on the lung tumor, the coexistence of a second malignancy was histologically proved in a second bronchoscopy. Resection of the lung tumor with complex lobectomy and lymphadenectomy was performed. After that, chemotherapy with four cycles of carboplatin supplemented with taxol was induced. The patient was discharged from the hospital with a stable remission of both tumor diseases. Restaging after six months showed no evidence of a tumor relapse. This is a very rare case of the coexistence of NHL and NSCLC; we will discuss the difficulty of diagnostic and treatment of both tumor diseases.

References

  • 1 Shikuwa S, Ito M, Nakashima M, Hamasaki K, Naito S, Sekine I, Fujii H. Autopsy case of co-localized tumors of hepatocellular carcinoma and malignant lymphoma.  J Gastroenterol. 1996;  31 (1) 129-132
  • 2 Tihan T, Filippa D A. Coexistence of renal cell carcinoma and malignant lymphoma. A causal relationship or coincidental occurrence?.  Cancer. 1996;  77 (11) 2325-2331
  • 3 Travis L B, Curtis R E, Boice JD J r, Hankey B F, Fraumeni J F. Jr . Second cancers following non-Hodgkin’s lymphoma.  Cancer. 1991;  67 2002-2009
  • 4 Shah I A, Haddad F S, Gani O S, Alfsen C C. An association between renal cell carcinoma and lymphoid malignancies: a case series of eight patients.  Cancer. 1997;  80 (5) 2421-2426
  • 5 Graziano F, Cellerino R, Menestrina F, Nicoli N, Gramazio A, Latini L, Piga A. Synchronous primary hepatic lymphoma and epidermoid lung carcinoma treated with chemotherapy and surgery.  Am J Clin Oncol. 1995;  18 (3) 194-198
  • 6 Ramesh V, Tanwar R K, Kaushal R, Rath G K, Vaid A, Pathak V, Choubey R P. Synchronous esophageal carcinoma with non Hodgkin’s lymphoma, problems with management.  Indian J Cancer. 1996;  33 (3) 153-156
  • 7 Travis L B, Curtis R E, Glimelius B, Holowaty E, Van Leeuwen F E, Lynch C F, Fraumeni J F. Jr . Second cancers among long-term survivors of non-Hodgkin’s lymphoma.  J Nat Cancer Inst. 1993;  85 1932-1937
  • 8 Kawashima O, Sakata S, Kamiyoshihara M, Maeshima A, Ishikawa S, Morishita Y. Primary pulmonary collision tumor including squamous cell carcinoma and T-cell lymphoma.  Lung Cancer. 1999;  23 (1) 67-70

Dr. Markus Rothenburger

Department of Cardiothoracic Surgery
University of Muenster

Albert-Schweitzer-Straße 33

48129 Muenster

Germany

Phone: +49 (251) 83-47401

Fax: +49 (251) 83-48316

Email: markus.rothenburger@thgms.uni-muenster.de