Planta Med 2002; 68(2): 169-171
DOI: 10.1055/s-2002-20249
Letter

© Georg Thieme Verlag Stuttgart · New York

Nematocidal Activity of Isoquinoline Alkaloids Against a Species of Diplogastridae

Rinako Matsuhashi1 , Tadaaki Satou1 , Kazuo Koike1 , Akihito Yokosuka2 , Yoshihiro Mimaki2 , Yutaka Sashida2 , Tamotsu Nikaido1
  • 1School of Pharmaceutical Sciences, Toho University, Chiba, Japan
  • 2School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
Further Information

Publication History

March 1, 2001

June 3, 2001

Publication Date:
22 February 2002 (online)

Abstract

We examined the nematocidal activity of various isoquinoline alkaloids. The method of evaluating nematocidal activity involved the microscopic examination of the state of larvae after the compound was administered to determine the minimum lethal concentration (MLC). In addition, cytotoxic activity (IC50) was examined using HL-60 culture cells. The compound dehydrocorydaline was found to have considerable nematocidal activity and weak cytotoxicity; its cytotoxicity value was equal to that of thiabendazole. We conclude that dehydrocorydaline, with its attractive balance between nematocidal activity and weak cytotoxicity, is the most promising of the tested compounds as a possible remedy for parasitic diseases.

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Tamotsu Nikaido

Department of Pharmacognosy

School of Pharmaceutical Sciences

Toho University

2-2-1 Miyama

Funabashi

Chiba 274-8510

Japan

Email: nikaido@phar.toho-u.ac.jp

Phone: +81-47-472-1391

Fax: +81-47-472-1404