Planta Med 2002; 68(2): 186-188
DOI: 10.1055/s-2002-20257
Letter

© Georg Thieme Verlag Stuttgart · New York

Constituents of the Leaves and Twigs of Ficus hispida

Sergio R. Peraza-Sánchez1 , Hee-Byung Chai1 , Young Geun Shin1 , Thawatchai Santisuk2 , Vichai Reutrakul3 , Norman R. Farnsworth1 , Geoffrey A. Cordell1 , John M. Pezzuto1 , A. Douglas Kinghorn1
  • 1Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, U.S.A.
  • 2Royal Forest Herbarium, Bangkok, Thailand
  • 3Department of Chemistry, Mahidol University, Bangkok, Thailand
Further Information

Publication History

March 16, 2001

June 24, 2001

Publication Date:
22 February 2002 (online)

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Abstract

A new norisoprenoid, ficustriol (1), and the known phenanthroindolizidine alkaloid O-methyltylophorinidine (2), were isolated from a CHCl3 extract of the leaves and twigs of Ficus hispida. O-Methyltylophorinidine showed potent cytotoxic activity when tested against a small panel of human cancer cells, while ficustriol was inactive. The structure and stereochemistry of 1 were determined using chemical and spectral methods.

References

Prof. A. Douglas Kinghorn, Ph. D., D.Sc.

Program for Collaborative Research in the Pharmaceutical Sciences

and Department of Medicinal Chemistry and Pharmacognosy

College of Pharmacy

University of Illinois at Chicago

833 South Wood Street (M/C 781)

Chicago

IL 60612

U.S.A.

Phone: +1-312-996-0914

Fax: +1-312-996-7107

Email: address: kinghorn@uic.edu.