Constituents of the Leaves and Twigs of Ficus hispida

Sergio R. Peraza-Sánchez; Hee-Byung Chai; Young Geun Shin; Thawatchai Santisuk; Vichai Reutrakul; Norman R. Farnsworth; Geoffrey A. Cordell; John M. Pezzuto; A. Douglas Kinghorn

doi:10.1055/s-2002-20257

Planta Med 2002; 68(2): 186-188
DOI: 10.1055/s-2002-20257

Letter

Constituents of the Leaves and Twigs of Ficus hispida

Sergio R. Peraza-Sánchez¹ , Hee-Byung Chai¹ , Young Geun Shin¹ , Thawatchai Santisuk² , Vichai Reutrakul³ , Norman R. Farnsworth¹ , Geoffrey A. Cordell¹ , John M. Pezzuto¹ , A. Douglas Kinghorn¹

¹Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, U.S.A.
²Royal Forest Herbarium, Bangkok, Thailand
³Department of Chemistry, Mahidol University, Bangkok, Thailand

Abstract

A new norisoprenoid, ficustriol (1), and the known phenanthroindolizidine alkaloid O-methyltylophorinidine (2), were isolated from a CHCl₃ extract of the leaves and twigs of Ficus hispida. O-Methyltylophorinidine showed potent cytotoxic activity when tested against a small panel of human cancer cells, while ficustriol was inactive. The structure and stereochemistry of 1 were determined using chemical and spectral methods.

Full Text

References

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Prof. A. Douglas Kinghorn, Ph. D., D.Sc.

Program for Collaborative Research in the Pharmaceutical Sciences

and Department of Medicinal Chemistry and Pharmacognosy

College of Pharmacy

University of Illinois at Chicago

833 South Wood Street (M/C 781)

Chicago

IL 60612

U.S.A.

Phone: +1-312-996-0914

Fax: +1-312-996-7107

Email: address: kinghorn@uic.edu.