A General Procedure for the Synthesis of 2-Substituted Pyrimidine-5-Carboxylic Esters

Pavel Zhichkin; David J. Fairfax; Shane A. Eisenbeis

doi:10.1055/s-2002-25767

SHORTPAPER

A General Procedure for the Synthesis of 2-Substituted Pyrimidine-5-Carboxylic Esters

Pavel Zhichkin^a, David J. Fairfax*^a, Shane A. Eisenbeis^b
^a Albany Molecular Research Inc., 21 Corporate Circle, PO Box 15098, Albany, NY 12212, USA
^b Pfizer Global Research and Development, Groton Laboratories, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA
Fax: +1(518)4640289; e-Mail: DavidF@albmolecular.com;

Abstract

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Abstract

A method for the synthesis of 2-substituted pyrimidine-5-carboxylic esters is described. The sodium salt of 3,3-dimethoxy-2-methoxycarbonylpropen-1-ol (3) has been found to react with a variety of amidinium salts to afford the corresponding 2-substituted pyrimidine-5-carboxylic esters.

Keywords

heterocycles - pyrimidines - condensation - amidinium salt - esters

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References

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