The Role of von Willebrand Factor in Platelet Function

Philip G. de Groot

doi:10.1055/s-2002-27815

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2002; 28(2): 133-138
DOI: 10.1055/s-2002-27815

The Role of von Willebrand Factor in Platelet Function

Philip G. de Groot

University Medical Center, Utrecht, The Netherlands

Abstract

ABSTRACT

von Willebrand factor (vWF) has essential functions in the very first stage of hemostasis. At the site of vascular damage vWF binds immediately to exposed collagens, thereby facilitating the adhesion of platelets. After a first layer of platelets has been formed, vWF is also crucial as a link between platelets in the forming thrombus. In this article, the current knowledge on the role of vWF in primary hemostasis is reviewed.

KEYWORDS

von Willebrand factor - platelets - platelet adhesion - glycoprotein receptors - von Willebrand disease

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References

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