The Use of Calcium Phosphates as a Bone Substitute Material in Trauma Surgery

F. W. Bloemers; P. Patka; F. C. Bakker; H. J. Th M. Haarman

doi:10.1055/s-2002-30633

Osteosynthesis and Trauma Care, Table of Contents

Osteosynthesis and Trauma Care 2002; 10(1): 33-37
DOI: 10.1055/s-2002-30633

Original Articles

The Use of Calcium Phosphates as a Bone Substitute Material in Trauma Surgery

F. W. Bloemers, P. Patka, F. C. Bakker, H. J. Th. M. Haarman

Department of Traumatology/Surgery, University Hospital Vu Medisch Centrum, Amsterdam, The Netherlands

Abstract

Bone defects caused by trauma can be filled with calcium phosphates. A variety of materials based on calcium phosphate composite are developed and investigated. The clinical use is essentially based on the good biocompatibility with bone tissue and the osteoconductive properties of these materials. Recently new materials are investigated for new applications. The combination of calcium phosphates and osteoinductive substances such as bone marrow and bone morphogenetic proteins are main topics of current research of bone substitutes. To achieve complete restoration of bone architecture, fully resorbable bone substitute materials are developed and clinically tested for treatment of bone defects. This article reports the latest promising developments in the use of calcium phosphates in surgery of trauma.

Key words

Calcium phosphates - Bone substitute material - Trauma

Schlüsselwörter

Calciumphosphat - Knochenersatzmaterial - Traumatologie

Full Text

References

1 Blokhuis T J, Den Boer F C, Bramer J. et al . Evaluation of strength of healing fractures with dual energy X-ray absorptiometry. Clin Orthop. 2000; 380 260-268
2 Bucholz R W. Clinical experience with bone graft substitutes. J Orthop Trauma. 1987; 1 260-262
3 Bucholz R W, Carlton A, Holmes E. Hydroxyapatite and tricalcium phosphate bone graft substitutes. Orthop Clin North Amer. 1987; 18 323-324
4 Bucholz R W, Carlton A, Holmes R. Interporous hydroxyapatite as a bone graft substitute in tibial plateau fractures. Clin Orthop. 1989; 240 53-62
5 Cockin J. Autologous bone grafting; complications at the donor site. J Bone Joint Surg [Br]. 1971; 53 153
6 Den Boer F C, Bramer J A, Patka P. et al . Quantification of fracture healing with three-dimensional computed tomography. Arch Orthop Trauma Surg. 1998; 117 345-350
7 Den Boer F C, Patka P, Bakker F C. et al . New segmental long bone defect model in sheep: quantitative analysis of healing with dual energy x-ray absorptiometry. J Orthop Res. 1999; 17 654-660
8 Den Boer F C, Patka P, Haarman H JThM. Bone induction using bone growth factors: bone morphogenetic proteins. Ned Tijdschr Geneeskd. 1996; 140 2390-2394
9 Dhert W JA. Retrieval studies on calcium phosphate-coated implants. Med Prog Technol. 1994; 2 143
10 Gao T J, Linholm T S, Kommonen B, Ragni P. et al . Enhanced healing of segmental tibial defects in sheep by a composite bone substitute composed of tricalcium phosphate cylinder, bone morphogenetic protein, and type 4 collagen. J Biomed Mater Res. 1996; 32 505-512
11 Goad M EP, Aiolova M, Tofighi A, Jacobs M, Lee D. Resorbable apatitic bone substitute material. Alpha-BSM is associated with rapid bone regrowth in defects of rabbit tibias. J Bone Miner Res. 1997; 12 (Suppl) 518
12 Grob D. Autologous bone transplantation: problems at the donor site. Unfallchirurg. 1986; 83 339-345
13 Guicheux J, Heymann D, TdQcane M, Gautier H, Faivre A, Daculsi G. Association of human growth hormone and calcium phosphate by dynamic compaction: in vitro biocompatibility and bioactivity. J Biomed Mater Res. 1997; 36 258-264
14 Grimandi G, Weiss P, Miller F, Daculsi G. In vitro evaluation of a new injectable calcium phosphate material. J Biomed Mater Res. 1998; 33 660-666
15 Hamanishi C, Kitamoto K, Ohura K, Tanaka S, Doi Y. Self setting, bioactive, and biodegradable TTCP-DCPD apatite cement. J Biomed Mater Res. 1996; 32 383-389
16 Hott M, Benoit N, Bernache-Assolant D, Rey C, Marie P J. Proliferation and differentiation of human trabecular osteoblastic cells on hydroxyapatite. J Biomed Mater Res. 1997; 37 508-516
17 Jarcho M. Calcium phosphate ceramics as hard tissue prosthetics. Clin Orthop. 1981; 157 259-278
18 Klein C PAT, Patka P, Wolke J GC. et al . Long-term in vivo study of plasma sprayed coatings on titanium alloys of TetraCP, HA and α-TCP. Biomaterials. 1994; 15 146-150
19 Lee D, Tofighi, Aiolova M. et al . α-BSM®: a biomimetic bone substitute and drug delivery vehicle. Clin Orthop. 1999; 367S 396-405
20 Leichter I, Loch B. Evaluation of the calcium phosphate ceramic implant by non-invasive techniques. Biomaterials. 1992; 13 478-482
21 Martin R B, Chapman M W, Sharkey N A, Zissimos S L, Bay B, Shors E C. Bone ingrowth and mechanical properties of corraline hydroxyapatite 1 year after implantation. Biomaterials. 1993; 14 314-348
22 Maruyama M. Hydroxyapatite clay used to fill the gap between implant and bone. J Bone Joint Surg [Br]. 1995; 77 213-228
23 Oghushi H, Goldberg V M, Caplan A I. Repair of bone defects with marrow cells and porous ceramics. Acta Orthop Scand. 1989; 60 334-339
24 Patka P. Bone replacement by calcium phosphate ceramics. An experimental study (thesis). Free University 1984
25 Patka P, Haarman H JThM, Elst vander M. Bone substitution and bone repair in trauma surgery. In: Wise D et al (eds). Encycl. handbook of biomaterials and bioengineering. Dekker, NY 1995; 639-663
26 Patka P, Haarman H JThM, Bakker F C. Bone transplantation and bone replacement materials. Ned Tijdschr Geneeskd. 1998; 142 893-896
27 Schwartz Z, Braun G, Kohavi D. et al . Effects of hydroxy-apatite implants on primary mineralization during rat tibial healing: Biochemical and morphometric analyses. J Biomed Mater Res. 1993; 27 1029-1083
28 Suh H, Lee C. Biodegradable ceramic-collagen composite implantated in rabbit tibiae. ASAIO J. 1995; 41 652-656
29 Spector M. Anorganic bovine bone and ceramic analogs of bone mineral as implants to facilitate bone regeneration. Clin Plast Surg. 1994; 21 437-444
30 Takechi M, Miyamoto Y, Ishikawa K. et al . Effects of added antibiotics on the basis properties of anti-wash-out-type fast setting calcium phosphate cement. J Biomed Mater Res. 1998; 39 308-316
31 Wang W, Ferguson D JP, Quinn J MW, Simpson A HRW, Athanasou N A. Biomaterial particle phagocytosis by bone-resorbing osteoclasts. J Bone Joint Surg [Br]. 1997; 79 849-856
32 Wippermann B W, Schratt H E, Donow C, Den Boer F C. α-BSM® und Hydroxylapatitkeramik granulat (HA) in einem Tibiasegmentdefekt beim Schaf. In: Oestern HJ, Rehm KE (eds). Abstractband der 61. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie. Springer 1997; 839-841

F. W. BloemersM.D.

VU Medisch Centrum

De Boelelaan 1117

Postbus 70 57

1007 MB Amsterdam

The Netherlands

Phone: +31-20-4 44 02 68

Fax: +31-20-4 44 02 74

Email: FWBloemers@Hotmail.com