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Synthesis 2002(8): 1007-1009
DOI: 10.1055/s-2002-31966
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

A Novel Synthesis of 2-Trichloromethylchromones and 7-Trichloromethylnorkhellin

Vyacheslav Ya. Sosnovskikh*, Boris I. Usachev
Department of Chemistry, Ural State University, 620083 Ekaterinburg, Russia
Fax: +7(3432)615978; e-Mail: Vyacheslav.Sosnovskikh@usu.ru;
Further Information

Publication History

Received 4 February 2002
Publication Date:
03 June 2002 (online)

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Abstract

The reaction of 2-hydroxyacetophenones with trichloroacetyl chloride in the presence of pyridine at -30 °C followed by treatment of the reaction mixture with potassium tert-butylate affords 2-hydroxy-2-trichloromethylchroman-4-ones. Dehydration then provides the 2-trichloromethyl-chromones.

Key words

condensation - 2-hydroxyacetophenones - 2-hydroxy-2-trichloromethylchroman-4-ones - 2-trichloromethylchromones

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Sosnovskikh, V. Ya.; Usachev, B. I.; Kodess, M. I. Izv. Akad. Nauk, Ser. Khim. 2002, in press.