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DOI: 10.1055/s-2002-32899
© Georg Thieme Verlag Stuttgart · New York
Sesquiterpene Lactone Glycosides, Eudesmanolides, and Other Constituents from Carpesium macrocephalum
Publication History
Received: October 5, 2001
Accepted: February 3, 2002
Publication Date:
22 July 2002 (online)
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Abstract
Two new sesquiterpene lactone glycosides and two new eudesmanolides, along with twelve known compounds were isolated from seeds of Carpesium macrocephalum. The structures of these new compounds were elucidated as 2α-O-β-D-glucopyranosyl-5α, 11αH-eudesma-4(15)-en-12,8β-olide (1), 2α-O-β-D-glucopyranosyl-5αH-eudesma-4(15),11(13)-dien-12,8β-olide (2), 2α-acetoxy-5α-hydroxy-11αH-eudesma-4(15)-en-12,8β-olide (3) and 2α,5α-dihydroxy-11αH-eudesma-4(15)-en-12,8β-olide (4) by spectroscopic methods including 2D NMR techniques (1H-1H COSY, 1H-1H NOESY, HMQC, HMBC) and chemical transformations. Compounds 1, 6, 8, 9 and 10 exhibited moderate antibacterial activity, while compound 4 showed appreciable cytotoxic activity against cultured SMMC-7721 (human hepatoma cell).
Key words
Carpesium macrocephalum - Compositae - eudesmanolide - sesquiterpene lactone glycosides - antibacterial activity - cytotoxic activity
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Prof. Zhong-Jian Jia
Department of Chemistry
Lanzhou University
Lanzhou, Gansu 730000
Peoples Republic of China
Email: Zhengrl@lzu.edu.cn
Fax: + 86-0931-8 912 582