Abstract
The synthesis of N -fluorenylmethoxycarbonyl-N ,S -dimethyl-l -Cysteine (1 ) [Fmoc,Me-Cys(Me)-OH] and N -fluorenylmethoxycarbonyl-N -methyl-S -acetamidomethyl-l -Cysteine (2 ) [Fmoc,Me-Cys(Acm)-OH] is
reported. The synthesis is characterized by a convenient two-step
procedure from (R )-thiazolidine-4-carboxylic
acid (3 ) via reduction and subsequent protection.
Crystals of 1 , which have been analyzed
by single-crystal X-ray crystallography, are obtained after a simple
crystallization at the end of the process, without purification
of intermediates.
Key words
amino acids - peptides - cysteine - protecting
groups
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