Synthesis of 1,4-Anhydro-2-deoxy-d-ribitol Derivatives from Thymidine Using Improved Preparation of Furanoid Glycals

Abstract

Preparation of furanoid glycal by elimination of the nucleobase from thymidine has been investigated. A number of catalysts for this reaction were tested, resulting in improved and scaleable synthesis. Hydrogenation of the resulting glycal afforded the 5-protected 1,4-anhydro-2-deoxy-d-ribitol derivative in a high yield.

Keywords

carbohydrates - furans - glycals - thymidine - hydrogenation - nucleosides

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