Stereospecific Synthesis of 3,3-Disubstituted Acrylonitriles by Heck Reaction

Abstract

The coupling reaction of 3-aryl (or heteroaryl) acrylonitriles with several aryl and heteroaryl iodides (Heck reaction) under Jeffery’s conditions has been studied as a concept to synthesize, in a stereospecific manner, trisubstituted olefins.

Key words

arylations - Heck reaction - heterocycles - Palladium catalysis - alkenes

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