Abstract
The total synthesis of the polyketide natural product callystatin
A and its novel analog C19-epi -callystatin
A is described. Our strategy features the use of an enantiomerically
pure oxabicyclo[3.2.1]oct-6-ene as a template
for the stereocontrolled preparation of the C15-C21 polypropionate
region.
Key words
total synthesis - natural products - asymmetric
synthesis - ring opening - stereoselectivity
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