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Planta Med 2002; 68(10): 932-934
DOI: 10.1055/s-2002-34930
Letter
© Georg Thieme Verlag Stuttgart · New York

Hepatoprotective and Free Radical Scavenging Activities of Prenylflavonoids, Coumarin, and Stilbene from Morus alba

Hyuncheol Oh1 , Eun-Kyung Ko2 , Jung-Yang Jun2 , Myung-Hoon Oh2 , Sung-Uk Park3 , Ki-Hong Kang2 , Ho-Sub Lee1 , Youn-Chul Kim2
  • 1Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Korea
  • 2MRRC and College of Pharmacy, Wonkwang University, Iksan, Korea
  • 3Spela Co. Ltd., Seocho-dong, Seocho-gu, Seoul, Korea
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Publication History

Received: February 1, 2002

Accepted: June 15, 2002

Publication Date:
21 October 2002 (online)

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Abstract

Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone B (2) and cudraflavone C (3), and oxyresveratrol (4). Compounds 1 and 4 showed superoxide scavenging effects with the IC50 values of 19.1 ± 3.6 and 3.81 ± 0.5 μM, respectively. Compound 4 exhibited a DPPH free radical scavenging effect (IC50 = 23.4 ± 1.5 μM). Compounds 2 and 4 showed hepatoprotective effects with EC50 values of 10.3 ± 0.42 and 32.3 ± 2.62 μM, respectively, on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.

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Prof. Dr. Youn-Chul Kim

MRRC and College of Pharmacy

Wonkwang University

Iksan 570-749

South Korea

Email: yckim@wonkwang.ac.kr

Fax: +82-63-852-8837