Planta Med 2002; 68(10): 916-920
DOI: 10.1055/s-2002-34951
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

An Isorhapontigenin Tetramer and a Novel Stilbene Dimer from Gnetum hainanense

Kai-Sheng Huang1 , Shan Zhou1 , Mao Lin1 , Ying-Hong Wang1
  • 1Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China
Further Information

Publication History

Received: February 8, 2002

Accepted: May 15, 2002

Publication Date:
21 October 2002 (online)

Abstract

The first isorhapontigenin tetramer, gnetuhainin R (1) and a novel dimeric stilbene, gnetuhainin S (2) were isolated from the lianas of Gnetum hainanense. Their structures were elucidated on the basis of spectroscopic and chemical evidence, especially 2D NMR analysis. The structure of 2 was further supported by X-ray crystallographic analysis. The anti-inflammatory activity of 1 has been tested, and it showed potent activity of histamine receptor antagonism.

References

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Prof. Mao Lin

Institute of Materia Medica

Chinese Academy of Medical Sciences

Peking Union Medical College

1 Xian Nong Tan Street

Beijing 100050

P. R. China

Email: linmao@imm.ac.cn

Phone: +(86-10)-63165326

Fax: +(86-10)-63017757