Zusammenfassung
Seit 1999 stehen die Medikamente Pramipexol und Ropinirol im Verdacht, bei Parkinson-Patienten
Schlafattacken auszulösen. Ziel unserer Studie war es zu prüfen, ob Schlafattacken
nicht grundsätzlich auch durch Micro-sleep-Episoden bei vorbestehender Tagesmüdigkeit
als Folge von - wie auch immer verursachtem - gestörtem Nachtschlaf erklärt werden
können. In Zusammenarbeit mit der Fachklinik Ichenhausen wurden deshalb in der Schmerzklinik
Enzensberg Patienten mit chronischen Schmerzen zu Tagesmüdigkeit, Einschlafneigung
und plötzlich unerwartetem Einschlafen befragt. Bei der Befragung von 37 Patienten
mit chronischem Schmerzsyndrom gaben über die Hälfte plötzliches Einschlafen tagsüber
an, in der Regel mit vorhergehender Müdigkeit. Vier Patienten (11 %) berichteten auch
über völlig überraschendes Einschlafen ohne subjektive Müdigkeit vorher. Alle vier
gaben die Einnahme einer Kombination aus verschiedenen Schmerzmitteln an. Somit kann
zumindest die Frage gestellt werden, ob es sich beim plötzlichen unerwarteten Einschlafen
um eine spezifische Medikamentenwirkung handelt oder ob eine chronische Übermüdung
bei Patienten mit chronischer Störung des Nachtschlafes zu dieser Symptomatik führt.
Abstract
Since 1999 Pramipexol and Ropinirol have been suspected of triggering sleep attacks
in relation to patients suffering from Parkinson disease. Our study aims to investigate,
wether episodes of micro sleep as a result of disordered night sleep - however it
may be caused - could be responsible. Therefore, patients with chronic pain treated
in an in-patient pain clinic were interviewed on excessive daytime sleepiness, proneness
to fall asleep and sudden-onset sleep. Data analysis included 37 questionnaires of
patients with chronic pain. More than the half of this patients stated that they sometimes
fall asleep during the day - as the rule after preceeding tiredness. Four patients
(11 %) reported to fall asleep completely surprising without preceeding tiredness.
All four patients had taken a combination of different pain drugs. Thus at least the
question can be asked, if a specific effect of the medication or if a chronic overfatigue
as an after-effect of chronic disorder of night sleep leads to this symptomatology.
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Dr. med. Ulrike Renz
Fachklinik Ichenhausen · Abt. Neurologie
Krumbacher Straße 45
89335 Ichenhausen
