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DOI: 10.1055/s-2002-35650
Tracheospasmolytic Activity of Viteosin-A and Vitexicarpin Isolated from Vitex trifolia
Publication History
Received: January 9, 2002
Accepted: July 13, 2002
Publication Date:
26 November 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200211/lookinside/thumbnails/10.1055-s-2002-35650-1.jpg)
Abstract
The n-hexane extract that has shown activity in the tracheospasmolytic bioassay was fractionated by solvent extraction and from the major active fraction two compounds were isolated and identified as viteosin-A and vitexicarpin. These compounds blocked spontaneous contraction of isolated male guinea pig trachea induced by histamine; however only vitexicarpin was active in a model using sensitized guinea pig trachea stimulated by ovalbumin up to minimum dose of 1.3 × 10-5 M. The result suggests that vitexicarpin is able to block effects of histamine released from sensitized mast cells possibly by stabilizing the mast cells membrane function.
References
-
1 Wahyuono S, Alam G, Ganjar G G, Hakim L, Timmerman H. Antiasthmatic Indonesian medicinal plants: Their tracheospasmolytic activity induced by histamine.
International Sendai Histamine Symposium ”Histamine Research in the New Millenium” . Sendai, Japan; November 22 - 25, 2000 - 2 Ono M, Ito Y, Nohara T. A labdane diterpene glycoside from fruit of Vitex rotundifolia . Phytochemistry. 1998; 1 207-9
- 3 Ono M, Sawamura H, Ito Y, Mizuki K, Nohara T. Diterpenoids from the fruits of Vitex trifolia . Phytochemistry. 2000; 55 873-7
- 4 Ono M, Yamamoto M, Yanaka T, Ito Y, Nohara T. Ten new labdane-type diterpenoids from the fruits of Vitex trifolia. Chem. Pharm. Bull.. 2001; 49 82-6
- 5 Ono M, Ito Y, Nohara T. Four new halimane-type diterpenes, vitetrifolin D-G, from the fruit of Vitex trifolia. Chem. Pharm. Bull.. 2001; 49 1220-2
- 6 Ono M, Ito Y, Kubo S, Nohara T. Two new iridoids from Viticis trifoliae fructus (fruits of Vitex rotundifolia L). Chem. Pharm. Bull.. 1997; 45 1094-6
- 7 Watanabe K, Takada Y, Matsuo N, Nishimura H. Rotundial, a new mosquito repellant from the leaves of Vitex rotundifolia. Biosci. Biotech. Biochem.. 1995; 50 1979-80
- 8 Ono M, Masuaka C, Ito Y, Nohara T. Antioxidative constituents from Viticis trifoliae fructus (fruits of Vitex rotundifolia L). Food Sci. Int. Tokyo. 1998; 4 9-13
- 9 You K M, Son K H, Chang H W, Kang S S, Kim H P. Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia inhibit mouse lymphocyte proliferation and growth of cells lines in vitro . Planta Medica. 1998; 64 546-50
- 10 Lee S J, Choi J H, Son K H, Chang H W, Kang S S, Kim H P. Suppresion of mouse lymphocyte proliferation in vitro by naturally-occurring biflavonoids. Life Sci.. 1995; 57 551-8
- 11 Bergendorff O, Sterner O. Spasmolytic flavonol from Artemisia arboretum . Planta Medica. 1995; 61 370-1
Dr. Subagus Wahyuono
Faculty of Pharmacy
Gadjah Mada University
Bulaksumur, Sekip Utara
Yogyakarta 55281
Indonesia
Email: Subagusw@yahoo.com
Fax: +62-274-543120