Planta Med 2002; 68(12): 1088-1091
DOI: 10.1055/s-2002-36350
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Antimalarial Agents from Plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva

Hong-Jie Zhang1 , Pamela A. Tamez1 , Zeynep Aydogmus1 , Ghee Teng Tan1 , Yoko Saikawa2 , Kimiko Hashimoto2 , Masaya Nakata2 , Nguyen Van Hung3 , Le Thi Xuan3 , Nguyen Manh Cuong4 , D. Doel Soejarto1 , John M. Pezzuto1 , Harry H. S.  Fong1
  • 1Program for Collaborative Research in Pharmaceutical Sciences, m/c 877, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, the University of Illinois at Chicago, Chicago, Illinois, USA
  • 2Faculty of Science and Technology, Department of Applied Chemistry, Keio University, Kohoku-ku, Yokohama, Japan
  • 3Institute of Chemistry, National Center for Science and Technology, Nghia Do, Tu Liem, Hanoi, Vietnam
  • 4Cuc Phuong National Park, Nho Quan District, Ninh Binh Province, Vietnam
Weitere Informationen

Publikationsverlauf

Received: April 25, 2002

Accepted: July 28, 2002

Publikationsdatum:
20. Dezember 2002 (online)

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Abstract

Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3α-hydroxyisohop-22(29)-en-24-oic acid, 3β-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, α-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC50 values below 1 ng/ml.