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Synthesis 2003(1): 0045-0048
DOI: 10.1055/s-2003-36250
DOI: 10.1055/s-2003-36250
PAPER
© Georg Thieme Verlag Stuttgart · New York
Trichloroisocyanuric Acid as a Cohalogenating Reagent: An Efficient Transformation of Alkenes into Chlorohydrins, β-Chloroethers and β-Chloroacetates
Further Information
Received
29 May 2002
Publication Date:
18 December 2002 (online)
Publication History
Publication Date:
18 December 2002 (online)
Abstract
The preparation of diverse β-chloroethers, β-chloroacetates, and chlorohydrins is efficiently achieved under mild conditions by reaction of alkenes with trichloroisocyanuric acid (0.34 mol equiv) in alcohols (MeOH, EtOH, i-PrOH, t-BuOH), acetic acid or aqueous acetone, respectively.
Key words
alkenes - electrophilic additions - esters - ethers - halogenation
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