Reduction of Carbonyl Compounds and Imines Using the CuCl₂·2H₂O-Li-DTBB (Cat.) Combination

Abstract

The reaction of different carbonyl compounds and imines­ with a mixture of copper(II) chloride dihydrate, an excess of lithium sand, and a catalytic amount of 4,4′-di-tert-butylbiphenyl (DTBB, 5 mol%) in THF at room temperature, led to the formation of the corresponding alcohols and amines, respectively. The process was also applied to the transformation of α,β-unsaturated carbonyl compounds into the corresponding saturated alcohols. The use of the deuterated copper salt CuCl₂·2D₂O allowed the preparation of the corresponding deuterated products.

Key words

ketones - aldehydes - imines - reductions - copper - alcohols - amines

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