Jatrophane Diterpenes from the Latex of Euphorbia obtusifolia with Inhibitory Activity on the Mammalian Mitochondrial Respiratory Chain

Liliana Betancur-Galvis; Javier Checa; J. Alberto Marco; Ernesto Estornell

doi:10.1055/s-2003-37701

Planta Medica, Table of Contents

Planta Med 2003; 69(2): 177-178
DOI: 10.1055/s-2003-37701

Letter

Jatrophane Diterpenes from the Latex of Euphorbia obtusifolia with Inhibitory Activity on the Mammalian Mitochondrial Respiratory Chain

Liliana Betancur-Galvis¹ , Javier Checa² , J. Alberto Marco² , Ernesto Estornell³

¹Grupo Infección y Cáncer, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
²Departamento de Química Orgánica Universidad de Valencia, Burjassot, Valencia, Spain
³Departamento de Bioquímica y Biología Molecular. Universidad de Valencia, Burjassot, Valencia, Spain

Abstract

Seven diterpenes isolated of the latex of the Euphorbia obtusifolia were evaluated as inhibitors of the NADH oxidase activity in submitochondrial particles from bovine heart. Compound 2, 2,3,5,7,8,9,15-heptahydroxyjatropha-6(17),11-diene-14-one 8,9-diacetate 7-isobutyrate 2,3-bis(2-methylbutyrate), was the most potent inhibitor with an inhibitory concentration (IC₅₀) value of 5.1 ± 0.2 μM. In the present study, some structure-activity trends are suggested for the inhibitory activity of these natural products on the mammalian mitochondrial respiratory chain.

Full Text

References

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Prof. Liliana Betancur-Galvis

Facultad de Medicina

Universidad de Antioquia

A. A. 1226

Medellín

Colombia

Email: labeta@catios.udea.edu.co

Fax: +574 5106062

Phone: +574 5106059