Repetitive transcranial magnetic stimulation (rTMS) has been shown to have a therapeutic effect on affective disorder and anxiety disorders. However, some reports have linked rTMS to a significant increase in anxiety in normal volunteers. This study investigates the effect of rTMS on anxiety and the use of acute and chronic paroxetine treatment on this animal model of anxiety. In normal rats, rTMS for 10 days induced anxiety, as shown by elevated plus maze, black and white box, and conditioned fear tests. This anxiety was suppressed by chronic, but not acute, paroxetine. These results suggest that rats receiving chronic rTMS treatment can be used as a model of anxiety and that the anxiety induced by rTMS might involve the serotonergic system.
Key words
Transcranial magnetic stimulation - anxiety - paroxetine - rats - chronic treatment - serotonin
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Jotaro Akiyoshi
Department of Neuropsychiatry
Oita Medical University
Hasama-Machi
Oita 879-5593
Japan
Phone: 81-97-586-5823
Fax: 81-97-549-3583
Email: akiyoshi@oita-med.ac.jp
