Colorectal Cancers in Children without any Predisposing Factors. A Report of Eight Cases and Review of the Literature

C. N. Radhakrishnan; J. Bruce

doi:10.1055/s-2003-38300

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Eur J Pediatr Surg 2003; 13(1): 66-68
DOI: 10.1055/s-2003-38300

Case Report

Georg Thieme Verlag Stuttart, New York · Masson Editeur Paris

Colorectal Cancers in Children without any Predisposing Factors. A Report of Eight Cases and Review of the Literature

C. N. Radhakrishnan¹ , J. Bruce¹

¹Department of Surgery, Royal Manchester Children's Hospital, Manchester, UK

Further Information

Publication History

Received: March 15, 2002

Accepted after Revision: May 15, 2002

Publication Date:
28 March 2003 (online)

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Abstract

Carcinoma of the colon is usually associated with conditions such as familial adenomatous polyposis, and ulcerative colitis. Primary carcinoma of the colon is very rare in children. A series of eight children with primary carcinoma of the colon is presented. The commonest symptom was right iliac fossa pain. All children had poorly differentiated, highly aggressive tumours. In spite of surgery and adjuvant treatment, the survival was dismal with all the children dying within one year of presentation.

Résumé

Le carcinome du côlon survient en général sur un terrain prédisposé (polypose familiale, colite ulcéreuse) et chez l'enfant, le carcinome primitif est très rare. Nous présentons une série de 8 enfants atteints d'un carcinome primaire du côlon. Le symptome le plus fréquent était une douleur de la fosse iliaque droite. Tous les enfants avaient une tumeur peu différenciée et agressive. Malgré la chirurgie et des traitements complémentaires, le pronostic du carcinome primaire chez l'enfant est sombre car tous les enfants sont décédés moins d'un an après le diagnostic.

Resumen

El carcinoma de colon se asocia generalmente con entidades como la poliposis adenomatosa familiar y la colitis ulcerosa. El carcinoma primario del colon es muy raro en niños. Presentamos una serie de 8 niños con carcinoma primario del colon. El síntoma más común fue el dolor en fosa iliaca derecha. Todos los niños tenían tumores poco diferenciados y altamente agresivos. A pesar de la cirugía y el tratamiento complementario todos los niños murieron en el primer año tras el diagnóstico.

Zusammenfassung

Das Auftreten eines Kolonkarzinoms ist bekannt bei familiärer polypöser Adenomatose, ulzerativer Kolitis oder Kolonkonduit. Dass jedoch ein Kolonkarzinom auch primär ohne Grunderkrankung im Kindesalter entstehen kann, ist äußerst ungewöhnlich.

In der vorliegenden Arbeit werden 8 Kinder mit einem primären Kolonkarzinom vorgestellt. Das häufigste Symptom waren Schmerzen im Bereich der rechten Fossa iliaca. Alle Kinder hatten gering differenzierte, hoch aggressive Tumoren. Trotz Chirurgie und angewandter Chemotherapie verstarben alle Kinder innerhalb eines Jahres.

Key words

Primary carcinoma - colon - children

Mots-clés

Carcinome primitif - côlon - enfant

Palabras clave

Carcinoma - colon - primario - niño

Schlüsselwörter

Primäres Kolonkarzinom - Kindesalter

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J. Bruce

Department of Paediatric Surgery, Royal Manchester Children's Hospital

Hospital Road

Pendlebury, Manchester M27 4HA

UK

Email: cnprk20@aol.com