Coagulation Factor Deficiencies and Pregnancy Loss

Aida Inbal; Laszlo Muszbek

doi:10.1055/s-2003-38832

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Semin Thromb Hemost 2003; 29(2): 171-174
DOI: 10.1055/s-2003-38832

Coagulation Factor Deficiencies and Pregnancy Loss

Aida Inbal¹ , Laszlo Muszbek²

¹Associate Professor, and Acting Director, Institute of Thrombosis and Hemostasis, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
²Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Science Center, University of Debrecen, Hungary

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Publication Date:
23 April 2003 (online)

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ABSTRACT

Of all the coagulation factor deficiencies, only deficiency of factor XIII (FXIII) and fibrinogen are associated with pregnancy loss. FXIII deficiency and a complete or partial deficiency of fibrinogen are associated with bleeding since childhood, impaired wound repair, and recurrent spontaneous abortions. Both FXIII and fibrinogen play an essential role in placental implantation and maintenance of pregnancy. The causes of miscarriages in FXIII or fibrinogen-deficient women is discussed and an appropriate treatment advocated.

KEYWORDS

Factor XIII deficiency - afibrinogenemia - miscarriages

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