Ostruthin: An Antimycobacterial Coumarin from the Roots of Peucedanum ostruthium

Andreas Schinkovitz; Simon Gibbons; Michael Stavri; Michael J. Cocksedge; Franz Bucar

doi:10.1055/s-2003-38876

Planta Medica, Table of Contents

Planta Med 2003; 69(4): 369-371
DOI: 10.1055/s-2003-38876

Letter

Ostruthin: An Antimycobacterial Coumarin from the Roots of Peucedanum ostruthium

Andreas Schinkovitz¹ , Simon Gibbons² , Michael Stavri² , Michael J. Cocksedge³ , Franz Bucar¹

¹Institute for Pharmacognosy, Karl-Franzens-University, Graz, Austria
²Centre for Pharmacognosy and Phytotherapy
³Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, U.K.

Abstract

Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis. Minimum inhibitory concentrations (MIC) ranged between 3.4 to 107.4 μM and were comparable to those of ethambutol and isoniazid. Imperatorin (8-isopent-2-enyloxy-6,7-furanocoumarin) showed no activity at concentrations up to 1.9 mM. Umbelliferone (7-hydroxycoumarin) was only weakly active (MIC = 0.79 mM).

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Ao. Univ.-Prof. Dr. Franz Bucar

Institute of Pharmacognosy

Karl-Franzens-University of Graz

Universitätsplatz 4/1

8010 Graz

Austria

Email: franz.bucar@uni-graz.at

Fax: +43-316-380-9860