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DOI: 10.1055/s-2003-38876
Ostruthin: An Antimycobacterial Coumarin from the Roots of Peucedanum ostruthium
Publication History
Received: August 16, 2002
Accepted: November 23, 2002
Publication Date:
23 April 2003 (online)
![](https://www.thieme-connect.de/media/plantamedica/200304/lookinside/thumbnails/10.1055-s-2003-38876-1.jpg)
Abstract
Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis. Minimum inhibitory concentrations (MIC) ranged between 3.4 to 107.4 μM and were comparable to those of ethambutol and isoniazid. Imperatorin (8-isopent-2-enyloxy-6,7-furanocoumarin) showed no activity at concentrations up to 1.9 mM. Umbelliferone (7-hydroxycoumarin) was only weakly active (MIC = 0.79 mM).
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Ao. Univ.-Prof. Dr. Franz Bucar
Institute of Pharmacognosy
Karl-Franzens-University of Graz
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8010 Graz
Austria
Email: franz.bucar@uni-graz.at
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