Abstract
Enantioselective desymmetrisation is one of the most effective
strategies for asymmetric synthesis. Typically, a meso starting
material with an internal mirror plane is desymmetrised by reaction
with a chiral reagent; excellent yields of products as single enantiomers
may be obtained. In fact, this approach is amenable to the synthesis
of compounds with any embedded improper element of symmetry (such
as a centre of symmetry). This review concentrates on the strategies,
which are available for the synthesis of centrosymmetric (and S
4 -symmetric) molecules and
describes methods for their desymmetrisation. Examples of syntheses
of biologically active molecules and natural products are used.
Key words
asymmetric synthesis - desymmetrisation - internal mirror
plane - natural product synthesis
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