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Synthesis 2003(10): 1603-1609
DOI: 10.1055/s-2003-40524
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Substituted Phenyl 2-Aminopyridine-3-sulfonates

Michael Fischer, Reinhard Troschütz*
Department of Medicinal Chemistry, Emil-Fischer-Center, Friedrich-Alexander-University, Schuhstraße 19, 91052 Erlangen, Germany
Fax: +49(9131)8522587; e-Mail: troschuetz@pharmazie.uni-erlangen.de;
Further Information

Publication History

Received 28 February 2003
Publication Date:
08 July 2003 (online)

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Abstract

A series of phenyl 2-aminopyridine-3-sulfonates 3 has been synthesized starting from phenyl cyanomethanesulfonate (5). Pinner reaction with 5 gave phenoxysulfonylketene aminal 4K which was cyclocondensed with a series of C3-biselectrophiles to yield the title compounds, which are of pharmaceutical and medicinal interest.

Key words

pyridines - condensation - tautomerisation - phenoxysulfonylketene aminals - 2-aminopyridine-3-sulfonates

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