Abstract
A 29-year-old woman with a prolactin microadenoma was under good control with bromocriptine (BCP) therapy until she became pregnant, when the treatment was stopped. During the third trimester of pregnancy the patient presented a unilateral visual loss and intermittent headaches. BCP was restarted and one week later she developed a complete ophthalmoplegia on the other side. The patient was submitted to an endoscopic transnasal transeptal resection of a hematoma and tumoral tissue in the pituitary region. One month after surgery, at 39 weeks of gestation, the patient spontaneously delivered a healthy girl weighing 3 kg, with an Apgar score of 9 and 10 at five minutes. This is the first case in the literature of a pregnant woman with second and third cranial nerve lesions, submitted to minimally invasive neuroendoscopic transnasal transsphenoidal approach in the third trimester of pregnancy.
Key words
Pregnancy - pituitary apolexy - endoscope - minimally invasive
References
-
1 Horvath E, Kovacs K. The adenohypophysis. In: Kovacs K, Asa SL (ed). Functional Endocrine Pathology. Boston: Blackwell Sciences 1991: 245-281
-
2
Molith M E.
Management of prolactinomas during pregnancy.
J Reprod Med.
1999;
44
1121-1126
-
3
Randeva H, Davis M, Prelevic G.
Prolactinoma and pregnancy.
Br J Obs Gyn.
2000;
107
1064-1068
-
4
Ester A D, Sanders T G, Vines F S.
Size and shape of the pituitary gland during pregnancy and post partum: Measurement with MR imaging.
Radiology.
1991;
181
531-532
-
5
Miki Y, Asato R, Okumura R.
Anterior pituitary gland in pregnancy: Hyperintensity at MR.
Radiology.
1993;
187
223-229
-
6
Dinç H, Esen F, Demirci A.
Pituitary dimensions and volume measurements in pregnancy and post partum.
Acta Radiol.
1998;
39
64-69
-
7
Vician L, Shupnik M, Gorski J.
Effects of estrogen on primary ovine pituitary cell cultures: Stimulation of prolactin secretion, synthesis, and preprolactin messenger ribonucleic acid activity.
Endocrinology.
1979;
104
736-743
-
8
Maurer R.
Relationship between estradiol, ergocryptine, and thyroid hormone: Effects on prolactin synthesis and prolactin messenger ribonucleic acid levels.
Endocrinology.
1982;
110
1515-1520
-
9
Rakoff J, Yen S.
Progesterone induced acute release of prolactin in estrogen primed ovariectomized women.
J Clin Endocrinol Metab.
1978;
47
918-922
-
10
Asa S, Penz C, Kovacs K, Ezrin C.
Prolactin cells in the human pituitary: a quantitative immunocytochemical analysis.
Arch Pathol Lab Med.
1982;
106
360-363
-
11
Pressman E, Zeidman S, Reddy U, Epstein J, Brem H.
Differentiating lymphocytic adenohypophysitis from pituitary adenoma in the peripartum patient.
J Reprod Med.
1995;
40
251-259
-
12
Thorner M O, Perryman R I, Rogol A D, Conway B P, Macleod R M, Login I S.
Rapid changes of prolactinoma volume after withdrawal and reinstitution of bromocriptine.
J Clin Endocrinol Metab.
1981;
53
480-483
-
13
Shanis B S, Check J H.
Relative resistance of a microprolactinoma to bromocriptine therapy during pregnancy.
Gynecol Endocrinol.
1996;
10
91-94
-
14
Gemzell C, Wang C F.
Outcome of pregnancy in women pituitary adenomas.
Fertil Steril.
1979;
31
363-372
-
15
Ahmed M, Al-Dossary E, Woodhouse N J.
Macroprolactinomas with suprasellar extension: effect of bromocriptine withdrawal during one or more pregnancies.
Fertil Steril.
1992;
58
492-497
-
16
Cunnah D, Besser M.
Management of prolactinoma.
Clin Endocrinol (Oxf).
1990;
34
231-235
-
17
Ruiz-Velasco V, Tolis G.
Pregnancy in hyperprolactinemic women.
Fertil Steril.
1984;
41
793-805
-
18
Molith M E.
Pregnancy and the hyperprolactinemic woman.
N Engl J Med.
1985;
312
1364-1370
-
19
Bergh T, Nillus S J, Enoksson P, Larson G, Wide L.
Bromocriptin-induced pregnancies in women with large prolactinomas.
Clin Endocrinol (Oxf).
1982;
17
625-631
-
20
Child D, Gordon H, Mashiter K, Joplin G.
Pregnancy, prolactin and pituitary tumors.
Br Med J.
1975;
4
87-89
-
21 Krupp P, Monka C, Richter K. The safety aspects of infertility treatments. Proc of the Second World Congress of Gynecology and Obstetrics, Rio de Janeiro,. October 1988
-
22
Konopka P, Raymond J, Meceron R.
Continuous administration of bromocriptine in the prevention of neurological complications in pregnant women with prolactinomas.
Am J Obstet Gynecol.
1983;
146
935-938
-
23 Musolino N, Bronstein M. Prolactinomas and pregnancy: Use of dopamine agonists: Bromocriptime and cabergoline. Proc of the 6th International Pituitary Congress, Long Beach, California. 1999
-
24
van Roon E, van der Vijver J C, Gerretsen G, Hekster R E, Waddendorff R A.
Rapid regression of a suprasellar estending prolactinoma after bromocriptine treatment during pregnancy.
Fertil Steril.
1981;
36
173-177
-
25
Crosignani P G, Mattei A M, Severini V, Cavioni V, Maggioni P, Testa G.
Long-term effects of time, medical treatment and pregnancy in 176 hyperprolactinemic women.
Eur J Obs Rep Biology.
1992;
40
175-180
-
26
Modena G, Portioli I.
Delivery after bromocriptine therapy.
Lancet.
1977;
2
558
-
27
Yuen B.
Bromocriptine, pituitary tumours, and pregnancy.
Lancet.
1978;
2
1314
-
28
Griffith R W, Turkalj I, Braun P.
Outcome of pregnancy in mothers given bromocriptine.
Br J Clin Pharmacol.
1978;
5
227-231
-
29
Parks D.
Drug therapy: bromocriptine.
New Engl J Med.
1979;
301
873-878
-
30
Turkalj I, Braun P, Krupp P.
Surveillance of bromocriptine in pregnancy.
JAMA.
1982;
247
1589-1591
-
31
Raymond J P, Goldsteine E, Kanopka P, Lelu M F, Merceron R E, Loria Y.
Follow up of children born of bromocriptine-treated mothers.
Horm Res.
1985;
22
239-246
-
32
Freeman R, Wezenter B, Silverstein M, Kuo D, Weiss K, Kantrowitz A.
Pregnancy-associated subacute hemorrhage into a prolactinoma resulting in diabetes insipidus.
Fertil Steril.
1992;
58
427-429
-
33
Labauge R, Pages A, Pages M, Ribstein J, Richard L.
Necrose hemorragique d'un adenome hypophysaire polyoncose endocrinienne.
Rev Neurol (Paris).
1982;
138
149-158
-
34
Saunders N.
Prolactinoma during pregnancy causing compression symptoms responding to bromocriptine therapy.
Postgrad Med J.
1985;
61
829-830
-
35
Wykes W.
Prolactinoma presenting with intermittent third nerve palsy.
Br J Ophthalmol.
1986;
70
706-707
-
36
Fong L, Fabinyi G.
Ophthalmic manifestations of pituitary apoplexy.
Med J Aust.
1985;
142
142-143
-
37
Crosignani P G, Ferrari C, Mattei A M.
Visual field defects and reduced visual acuity during pregnancy in two patients with prolactinoma: rapid regression of symptoms under bromocriptine. Case report.
Br J Obstet Gynecol.
1984;
91
821-823
-
38
Holgren U, Bergstrand G, Hagenfeldt K, Werner S.
Women with prolactinoma - effect of pregnancy and lactation on serum prolactin and tumor growth.
Acta Endocrinol.
1986;
111
452-459
-
39
Rasmussen C, Bergh T, Wide L.
Prolactin secretion and menstrual function after long-term bromocriptine treatment.
Fertil Steril.
1987;
48
550-554
-
40
Crosignani P, Mattei A, Scarduelli C, Cavioni V, Boracchi P.
Is pregnancy the best treatment for hyperprolactinaemia?.
Human Reprod.
1989;
4
910-912
-
41
Divers W, Yen S.
Prolactin-producing microadenomas in pregnancy.
Obstet Gynecol.
1983;
61
425-429
-
42
Kupersmith M J, Rosemberg C, Keimberg D.
Visual loss in pregnant women with pituitary adenomas.
Ann Intern Med.
1994;
121
437
-
43
Rjosk H, Fahlbusch R, Werder K.
Influence of pregnancies on prolactinomas.
Acta Endocrinol.
1982;
100
337-346
-
44
Canales E S, Garcia I C, Ruiz J E, Zarate A.
Bromocriptine as prophylactic therapy in prolactinoma during pregnancy.
Fertil Steril.
1981;
36
524-526
-
45
Bergh T, Nillius S, Larsson S, Wide L.
Effects of bromocriptine induced pregnancy on prolactin secreting pituitary tumors.
Acta Endocrinol (Copenh).
1981;
98
333-338
-
46
Goodman L A, Chang R J.
Pregnancy after bromocriptine induced reduction of an extrasellar prolactin-secreting pituitary macroadenomas.
Obstet Gynecol.
1984;
64 (3 Suppl)
2s-7s
-
47
Coremblum B.
Successful outcome of ergocryptine-induced pregnancies in twenty-one women with prolactina-secreting pituitary adenomas.
Fertil Steril.
1979;
32
183-186
-
48
Glick R P, Tiesi J Á.
Subacute pituitary apoplexy: clinical and magnetic resonance imaging characteristics.
Neurosurgery.
1990;
27
214-219
-
49
Onesti S T, Wisniewski T, Post K D.
Clinical versus subclinical pituitary apoplexy: presentation, surgical management, and outcome in 21 patients.
Neurosurg.
1990;
26
990-996
-
50
Gondim J, Pinheiro I.
Neuroendoscopic endonasal transseptal approach to the sellar region: study of 30 cases.
Arq Neuropsiquiatr.
2001;
59
901-904
Dr. J. Gondim
Instituto de Neurologia
1805 Pereira Filgueiras Street
Fortaleza
Brazil 60.181-560
Phone: +55-85-265-5768
Fax: +55-85-265-5768
Email: jagondim@secrel.com.b