Brønsted Acid-Mediated Synthesis of α-Amino Phosphonates under Solvent-Free Conditions

Takahiko Akiyama; Machiko Sanada; Kohei Fuchibe

doi:10.1055/s-2003-40858

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Brønsted Acid-Mediated Synthesis of α-Amino Phosphonates under Solvent-Free Conditions

Takahiko Akiyama*, Machiko Sanada, Kohei Fuchibe
Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo 171-8588, Japan
Fax: +81(3)59921029; e-Mail: takahiko.akiyama@gakushuin.ac.jp;

Abstract

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Abstract

Three-component reactions of aldehydes, amine, and diethyl phosphite by means of CF₃COOH under the solvent-free conditions afforded α-amino phosphonates in excellent yields.

Key words

phosphonates - imines - nucleophilic additions - amine - diethyl phosphite

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For the synthesis of α-amino phosphonate under solvent-free conditions, see; refs. [15-17]

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Acetophenone did not react under the same reaction conditions.