Abstract
The reaction of N -Boc-α-amino
acids with aryllithium reagents followed by removal of the nitrogen
protecting group provides enantiomerically pure α-amino
aryl ketones as their corresponding HCl salts. This practical two-step
sequence gives rapid access to a pharmaceutically interesting class
of compounds from commercially available starting materials.
Key words
arylations - amino acids - lithiation - ketones - nucleophilic additions
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