Role of Coagulation and Fibrinolytic System in Prostate Cancer

Manish Kohli; Varsha Kaushal; Paulette Mehta

doi:10.1055/s-2003-40968

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2003; 29(3): 301-308
DOI: 10.1055/s-2003-40968

Role of Coagulation and Fibrinolytic System in Prostate Cancer

Manish Kohli¹ , Varsha Kaushal² , Paulette Mehta²

¹Staff Physician, Division of Hematology/Oncology, Department of Medicine, Central Arkansas Veterans Healthcare System, and Assistant Professor of Medicine, Division of Hematology/Oncology, University of Arkansas for Medical Sciences
²Central Arkansas Veterans Healthcare System and Division of Hematology/Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas

Abstract

ABSTRACT

Patients with prostate carcinoma paradoxically have both a hypercoagulable state and a bleeding diathesis. Hypercoagulability manifested by venous and arterial thrombosis has been documented in several large clinical trials. However, many investigators have reported a high risk of postoperative bleeding in prostate cancer patients. Disseminated intravascular coagulopathy has also been commonly noted at different clinical stages of this indolent cancer. In this article we review clinical, laboratory, and experimental evidence for abnormalities of various components of the coagulation and plasminogen pathways and analyze their contribution in prostate cancer growth, progression, and angiogenesis. Finally, we propose potential therapeutic antiangiogenic strategies in patients with prostate cancer.

KEYWORDS

Prostate cancer - hypercoagulability - bleeding - fibrinolysis - angiogenesis

Full Text

References

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